Abstract

1,3-Indenedione has been reacted with p-aminobenzaldehyde to give the corresponding p-aminobenzylidine-1,3-indenedione, treatment of which with paraformaldehyde and trifluroacetic acid has led to the Tröger’s base analogue. Treatment of that compound with dimethyl sulfate, acetic anhydride, benzoyl chloride, or trifluroacetic anhydride can afford the correspondingN,N′-disubstituted phenhomazines. Complexation of the Tröger’s base with ferric nitrate trihydrate or nickel chloride hexahydrate has resulted in the corresponding complexes. The structures of all compounds have been confirmed by their elemental analyses and spectral data. All the newly synthesized Tröger’s base and the derived N,N′-disubstituted phenhomazines have been tested for anticancer activity.

中文翻译：

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基于Tröger's碱和N，N'-双取代苯并恶嗪候选物的新型大环茚酮的合成，表征和抗癌活性

摘要

1,3-茚二酮已与对氨基苯甲醛反应生成相应的对氨基苯甲基-1,3-茚二酮，用低聚甲醛和三氟乙酸对其进行处理得到了Tröger的碱基类似物。用硫酸二甲酯，乙酸酐，苯甲酰氯或三氟乙酸酐处理该化合物可得到相应的N，N′-二取代的苯并azine嗪。Tröger碱与三水合硝酸铁或六水合氯化镍的络合生成了相应的络合物。所有化合物的结构均已通过其元素分析和光谱数据证实。所有新合成的Tröger基和派生的N，N已经测试了'-二取代的吩嗪嗪的抗癌活性。