Abstract—Prostate cancer (PCa) is a very common type of cancer among men. It was revealed that Interleukin-4 (IL-4) and interleukin-1 receptor antagonist (IL-1Ra) genes had important functions such as development of prostate cells or regulating the inflammatory processes. The important role of cytokines in inflammatory mechanisms leads to the possibility that polymorphisms of these genes may contribute to the formation of prostate cancer. In this study, we aimed to investigate the association of variable number tandem repeat (VNTR) polymorphisms in the IL-1Ra and IL-4 genes with PCa in Turkish population. 70 prostate cancer patients and 110 healthy controls were involved in a case-control study. Genotype distributions and allele frequencies for the IL-1Ra intron 2 (rs2234663) and IL-4 intron 3 (rs79071878) VNTR polymorphisms were analyzed by using PCR technique. No statistically significant association was identified for both IL-1Ra intron 2 and IL-4 intron 3 polymorphisms between PCa patients and controls (P > 0.05). IL-1Ra intron 2 and IL-4 intron-3 VNTR polymorphisms were not found to be risk factors in prostate cancer and its development in Turkish population.

摘要—前列腺癌（PCa）是男性中非常常见的一种癌症。结果表明，白介素-4（IL-4）和白介素-1受体拮抗剂（IL-1Ra）基因具有重要功能，例如前列腺细胞的发育或调节炎症过程。细胞因子在炎症机制中的重要作用导致这些基因的多态性可能有助于前列腺癌的形成。在这项研究中，我们旨在研究IL-1Ra和IL-4中可变数目串联重复序列（VNTR）多态性的关联土耳其人群中具有PCa的基因。一项病例对照研究涉及70位前列腺癌患者和110位健康对照。使用PCR技术分析了IL-1Ra内含子2（rs2234663）和IL-4内含子3（rs79071878）VNTR多态性的基因型分布和等位基因频率。在PCa患者和对照组之间，IL-1Ra内含子2和IL-4内含子3多态性均未发现统计学上的显着相关性（P > 0.05）。IL-1Ra内含子2和IL-4内含子3 VNTR多态性未发现是前列腺癌及其在土耳其人口中发展的危险因素。