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Optimization of inulin production process parameters using response surface methodology
Future Journal of Pharmaceutical Sciences ( IF 3.4 ) Pub Date : 2020-10-09 , DOI: 10.1186/s43094-020-00087-1
Wasim Akram , Navneet Garud

Chicory is one of the major source of inulin. In our study, Box–Behnken model/response surface analysis (RSM) was used for the optimization of spray drying process variables to get the maximum inulin yield from chicory (Cichorium intybus L.). For this investigation, the investigational plan utilized three process variables drying temperature (115–125 °C), creep speed (20–24 rpm), and pressure (0.02–0.04 MPa). The optimal variables established by applying the Box–Behnken model were as follows: drying temperature 119.20 °C, creep speed 21.64 rpm, and pressure 0.03 MPa. The obtained powdered inulin by spray drying was investigated for the yield value, identification, size, and surface morphology of the particle. The inulin obtained from the spray drying process consists of a fine molecule-sized white powder. Instead, the drying methods shows a significant effect on the morphology and internal configuration of the powdered inulin, as the inulin obtained from spray drying was of a widespread and uniform size and shape, with a rough surface on increase in temperature and smoother surface while increasing the creep speed. The findings indicate that the spray drying with optimum parameters resulted in maximum product yield. The outcomes of the study concluded that the product yield through spray drying technique under optimized condition is optimal as compared to other drying technique. Hence, this technique may be applied at commercial scale for the production of inulin.

中文翻译:

使用响应面法优化菊粉生产工艺参数

菊苣是菊粉的主要来源之一。在我们的研究中,Box-Behnken模型/响应表面分析(RSM)用于优化喷雾干燥工艺变量,以从菊苣(菊苣(Cichorium intybus L.))获得最大菊粉产量。对于这项研究,研究计划利用了三个过程变量:干燥温度(115-125°C),蠕变速度(20-24 rpm)和压力(0.02-0.04 MPa)。通过应用Box–Behnken模型建立的最佳变量如下:干燥温度119.20°C,蠕变速度21.64 rpm,压力0.03 MPa。研究通过喷雾干燥获得的菊粉粉末的产率值,鉴定,尺寸和表面形态。从喷雾干燥过程中获得的菊粉由细分子大小的白色粉末组成。代替,干燥方法对菊粉粉的形态和内部结构有显着影响,因为通过喷雾干燥获得的菊粉具有广泛且均匀的尺寸和形状,温度升高时表面粗糙,表面光滑,同时蠕变增加速度。研究结果表明,采用最佳参数进行喷雾干燥可获得最大的产品收率。研究结果表明,与其他干燥技术相比,在最佳条件下通过喷雾干燥技术获得的产品收率最佳。因此,该技术可以商业规模应用于菊粉的生产。温度升高时表面粗糙,表面光滑,同时加快蠕变速度。研究结果表明,采用最佳参数进行喷雾干燥可获得最大的产品收率。研究结果表明,与其他干燥技术相比,在最佳条件下通过喷雾干燥技术获得的产品收率最佳。因此,该技术可以商业规模应用于菊粉的生产。温度升高时表面粗糙,表面光滑,同时加快蠕变速度。研究结果表明,采用最佳参数进行喷雾干燥可获得最大的产品收率。研究结果表明,与其他干燥技术相比,在最佳条件下通过喷雾干燥技术获得的产品收率最佳。因此,该技术可以商业规模应用于菊粉的生产。
更新日期:2020-10-11
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