The content of triacylglycerol (TAG) in the liver is known to rapidly increase after a single bout of exercise followed by recovery to sedentary levels. The response of other hepatic lipids, and acyl chain composition of lipid classes, would provide a deeper understanding of the response of hepatic lipid metabolism to acute exercise. Female mice performed a single bout of continuous exercise (CE), high-intensity interval exercise (HIIE), or no exercise (CON). The total content of various lipids in the liver, and fatty acids within lipid classes, were measured in tissues collected 3 h after exercise (Day 1) and the day following exercise (Day 2). The total concentration of TAG rose on Day 1 after exercise (P < 0.05), with a greater elevation in HIIE than CE (P < 0.05), followed by a decline toward CON levels on Day 2. The total concentration of other measured lipid classes was not significantly altered by exercise. However, n-6 polyunsaturated fatty acid relative abundance in diacylglycerol (DAG) was increased by HIIE (P < 0.05). In CON liver, TAG content was positively correlated with DAG and phosphatidylethanolamine (P < 0.05), while these statistical associations were disrupted in exercised mice on Day 1. The response of lipid metabolism to exercise involves the coordination of metabolism between various tissues, and the lipid metabolism response to acute exercise places a metabolic burden upon the liver. The present findings describe how the liver copes with this metabolic challenge. The flexibility of the TAG pool size in the liver, and other remodeling of the hepatic lipidome, may be fundamental components of the physiological response to intense exercise.

中文翻译：

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小鼠的急性运动以强度依赖性方式瞬时重塑肝脏脂质组

已知肝脏中三酰甘油 (TAG) 的含量在一次运动后迅速增加，然后恢复到久坐不动的水平。其他肝脏脂质的反应，以及脂质类别的酰基链组成，将有助于更深入地了解肝脏脂质代谢对急性运动的反应。雌性小鼠进行一次连续运动 (CE)、高强度间歇运动 (HIIE) 或不运动 (CON)。在运动后 3 小时（第 1 天）和运动后一天（第 2 天）收集的组织中测量肝脏中各种脂质的总含量以及脂质类别中的脂肪酸。运动后第 1 天 TAG 的总浓度上升（P < 0.05），HIIE 的升高高于 CE（P < 0.05），然后在第 2 天下降到 CON 水平。其他测量的脂质类别的总浓度没有因运动而显着改变。然而，HIIE 增加了二酰基甘油 (DAG) 中 n-6 多不饱和脂肪酸的相对丰度（P < 0.05）。在 CON 肝脏中，TAG 含量与 DAG 和磷脂酰乙醇胺呈正相关（P < 0.05），而这些统计关联在第 1 天在运动小鼠中被破坏。对急性运动的脂质代谢反应给肝脏带来代谢负担。目前的研究结果描述了肝脏如何应对这种代谢挑战。肝脏中 TAG 池大小的灵活性，以及​​肝脏脂质组的其他重构，