Accuracy improvement in XRF analysis for the quantification of elements ranging from tenths to thousands μg g−1 in human tissues using different matrix reference materials,Journal of Analytical Atomic Spectrometry

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Accuracy improvement in XRF analysis for the quantification of elements ranging from tenths to thousands μg g−1 in human tissues using different matrix reference materials
Journal of Analytical Atomic Spectrometry ( IF 3.1 ) Pub Date : 2020-10-09 , DOI: 10.1039/d0ja00307g
Jorge Machado _{1,

2,

3,

4,

5} , Patrícia Miguel Carvalho _{1,

2,

3,

4,

5} , Ana Félix _{5,

6,

7,

8,

9} , Delfin Doutel _{5,

8,

9,

10,

11} , José Paulo Santos _{1,

2,

3,

4,

5} , Maria Luísa Carvalho _{1,

2,

3,

4,

5} , Sofia Pessanha _{1,

2,

3,

4,

5}

Affiliation

In this work, we aim at achieving the most accurate quantitative determination of elements in human tissues by means of X-ray Fluorescence spectrometry using the external calibration approach. A calibration curve built using a set of certified reference materials (CRM) of animal tissue was compared with the one obtained with a set of CRMs of plants and leaves with lower atomic number Z but with correction of the matrix using the scattering peaks of the X-ray tube anode. Finally, a calibration curve combining the two sets of CRMs was built and the accuracy of the quantification using the three methods was compared and a more precise method of quantification was obtained. This improved approach was tested on five paired samples of normal and tumour human tissue. Despite the high heterogeneity of the samples, and given the improvement in accuracy of the measurements, significant differences were found in the elemental concentration of low-Z elements.

中文翻译：

XRF分析的准确性提高，可使用不同的基质参考材料定量分析人体组织中十分之一到数千μgg-1的元素

在这项工作中，我们旨在通过使用外部校准方法的X射线荧光光谱法实现人体组织中元素的最准确定量测定。将使用一组经过认证的动物组织参考物质（CRM）建立的校准曲线与通过一组具有较低原子序数Z的植物和叶子的CRM所获得的校准曲线进行比较但是使用X射线管阳极的散射峰对矩阵进行校正。最后，建立了结合两组CRM的校准曲线，并比较了使用这三种方法的定量准确性，并获得了更精确的定量方法。在五对成对的正常和肿瘤人组织样品上测试了这种改进的方法。尽管样品具有很高的异质性，并且由于测量精度的提高，但低Z元素的元素浓度仍存在显着差异。

更新日期：2020-11-03

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