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Predicting the survival in patients with malignant pleural effusion undergoing indwelling pleural catheter insertion
Annals of Thoracic Medicine ( IF 2.3 ) Pub Date : 2020-10-01 , DOI: 10.4103/atm.atm_289_20 MuhammadJunaid Akram , Usman Khalid , MohammadBilal Ashraf , MuhammadAbu Bakar , FaheemMahmood Butt , Faheem Khan
CONTEXT: Malignant pleural effusion (MPE) is a common comorbid condition in advanced malignancies with variable survival.
AIMS: The aim of this study was to predict the survival in patients with MPE undergoing indwelling pleural catheter (IPC) insertion.
SETTINGS AND DESIGN: This was a cross-sectional study conducted at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
METHODS: One hundred and ten patients with MPE who underwent IPC insertion from January 2011 to December 2019 were reviewed. Kaplan–Meier method was used to determine the overall survival (OS) of the patient's cohort with respect to LENT score.
STATISTICAL ANALYSIS USED: The IBM SPSS version 20 was used for statistical analysis.
RESULTS: We retrospectively reviewed 110 patients who underwent IPC insertion for MPE, with a mean age of 49 ± 15 years. 76 (69.1%) patients were females, of which majority 59 (53.6%) had a primary diagnosis of breast cancer. The LENT score was used for risk stratification, and Kaplan–Meier survival curves were used to predict the OS. The proportion of patients with low-risk LENT score had 91%, 58%, and 29% survival, the moderate-risk group had 76%, 52%, and 14% survival, and in the high-risk group, 61%, 15%, and 0% patients survived at 1, 3, and 6 months, respectively. In addition, there was a statistically significant survival difference (P = 0.05) in patients who received chemotherapy pre- and post-IPC insertion.
CONCLUSIONS: LENT score seems to be an easy and attainable tool, capable of predicting the survival of the patients with MPE quite accurately. It can be helpful in palliating the symptoms of patients with advanced malignancies by modifying the treatment strategies.
中文翻译：
预测留置胸腔导管插入恶性胸腔积液患者的生存
背景：恶性胸腔积液（MPE）是存活率可变的晚期恶性肿瘤的常见合并症。
目的：本研究的目的是预测接受留置胸膜导管（IPC）插入的MPE患者的生存率。
场所和设计：这是在巴基斯坦拉合尔的Shaukat Khanum纪念癌症医院和研究中心进行的横断面研究。
方法：对2011年1月至2019年12月行IPC置入术的110例MPE患者进行回顾。Kaplan–Meier方法用于确定患者队列相对于LENT分数的总生存期（OS）。
使用的统计分析： IBM SPSS版本20用于统计分析。
结果：我们回顾性分析了110例接受IPC插入的MPE患者，平均年龄为49±15岁。76名（69.1％）患者为女性，其中大多数（59.6％）患有乳腺癌。LENT评分用于风险分层，Kaplan–Meier生存曲线用于预测OS。低危LENT评分的患者生存率分别为91％，58％和29％，中危组的生存率为76％，52％和14％，高危组为61％， 15％和0％的患者分别在1、3和6个月生存。此外，接受IPC前后化疗的患者生存率差异有统计学意义（P = 0.05）。
结论：LENT评分似乎是一种容易获得的工具，能够相当准确地预测MPE患者的生存率。通过修改治疗策略，有助于缓解晚期恶性肿瘤患者的症状。
更新日期：2020-10-11
Annals of Thoracic Medicine ( IF 2.3 ) Pub Date : 2020-10-01 , DOI: 10.4103/atm.atm_289_20 MuhammadJunaid Akram , Usman Khalid , MohammadBilal Ashraf , MuhammadAbu Bakar , FaheemMahmood Butt , Faheem Khan
CONTEXT: Malignant pleural effusion (MPE) is a common comorbid condition in advanced malignancies with variable survival.
AIMS: The aim of this study was to predict the survival in patients with MPE undergoing indwelling pleural catheter (IPC) insertion.
SETTINGS AND DESIGN: This was a cross-sectional study conducted at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
METHODS: One hundred and ten patients with MPE who underwent IPC insertion from January 2011 to December 2019 were reviewed. Kaplan–Meier method was used to determine the overall survival (OS) of the patient's cohort with respect to LENT score.
STATISTICAL ANALYSIS USED: The IBM SPSS version 20 was used for statistical analysis.
RESULTS: We retrospectively reviewed 110 patients who underwent IPC insertion for MPE, with a mean age of 49 ± 15 years. 76 (69.1%) patients were females, of which majority 59 (53.6%) had a primary diagnosis of breast cancer. The LENT score was used for risk stratification, and Kaplan–Meier survival curves were used to predict the OS. The proportion of patients with low-risk LENT score had 91%, 58%, and 29% survival, the moderate-risk group had 76%, 52%, and 14% survival, and in the high-risk group, 61%, 15%, and 0% patients survived at 1, 3, and 6 months, respectively. In addition, there was a statistically significant survival difference (P = 0.05) in patients who received chemotherapy pre- and post-IPC insertion.
CONCLUSIONS: LENT score seems to be an easy and attainable tool, capable of predicting the survival of the patients with MPE quite accurately. It can be helpful in palliating the symptoms of patients with advanced malignancies by modifying the treatment strategies.
中文翻译：
预测留置胸腔导管插入恶性胸腔积液患者的生存
背景：恶性胸腔积液（MPE）是存活率可变的晚期恶性肿瘤的常见合并症。
目的：本研究的目的是预测接受留置胸膜导管（IPC）插入的MPE患者的生存率。
场所和设计：这是在巴基斯坦拉合尔的Shaukat Khanum纪念癌症医院和研究中心进行的横断面研究。
方法：对2011年1月至2019年12月行IPC置入术的110例MPE患者进行回顾。Kaplan–Meier方法用于确定患者队列相对于LENT分数的总生存期（OS）。
使用的统计分析： IBM SPSS版本20用于统计分析。
结果：我们回顾性分析了110例接受IPC插入的MPE患者，平均年龄为49±15岁。76名（69.1％）患者为女性，其中大多数（59.6％）患有乳腺癌。LENT评分用于风险分层，Kaplan–Meier生存曲线用于预测OS。低危LENT评分的患者生存率分别为91％，58％和29％，中危组的生存率为76％，52％和14％，高危组为61％， 15％和0％的患者分别在1、3和6个月生存。此外，接受IPC前后化疗的患者生存率差异有统计学意义（P = 0.05）。
结论：LENT评分似乎是一种容易获得的工具，能够相当准确地预测MPE患者的生存率。通过修改治疗策略，有助于缓解晚期恶性肿瘤患者的症状。
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