INTRODUCTION: Although sleep disorders in chronic obstructive pulmonary disease (COPD) are common, no study has comprehensively evaluated sleep disorders in COPD, and there are no screening tools available for COPD patients. Global sleep assessment questionnaire (GSAQ) is one of the best screening tools for the general population.
AIMS AND OBJECTIVES: The aims and objectives of the study were to find (i) the prevalence of sleep disorders in COPD based on GSAQ score; (ii) if the GSAQ score in COPD is high compared to healthy adult population; (iii) the prevalence of insomnia, obstructive sleep apnea (OSA), restless leg syndrome (RLS), and depression in COPD patients; and (iv) the sensitivity and specificity of GSAQ.
METHODS: This was a prospective case–control study where GSAQ is administered to 100 stable COPD and 50 healthy individuals. The presence of sleep disorder in COPD was further confirmed based on the diagnostic criteria and polysomnography.
RESULTS: GSAQ was positive in 68% of the COPD patients compared to 16% of the matched healthy adults (P < 0.001). The sleep disturbance was confirmed in 66 COPD patients. Insomnia, OSA, RLS, depression/anxiety, and overlap of two or more disorder were seen in 39, 13, 30, 22, and 31 patients, respectively. The overall sensitivity/specificity of GSAQ for sleep disturbances in COPD was 90.9%/70.58%, respectively. The sensitivity/specificity of GSAQ for insomnia, OSA, RLS, and anxiety/depression was 87/75%, 77/67%, 90/80%, and 91/65%, respectively.
CONCLUSION: Sleep disorders in COPD patients are significantly high. GSAQ is a good screening tool for detecting the presence of disturbed sleep in COPD. Overlap of two or more sleep disorders is common in COPD.


中文翻译：

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慢性阻塞性肺疾病中睡眠障碍的患病率和全球睡眠评估问卷的实用性：一项观察性病例对照研究


简介：尽管慢性阻塞性肺疾病（COPD）的睡眠障碍很常见，但尚无一项研究全面评估COPD的睡眠障碍，也没有针对COPD患者的筛查工具。全球睡眠评估问卷（GSAQ）是针对一般人群的最佳筛查工具之一。
目的和目的：本研究的目的是发现：（i）基于GSAQ评分的COPD睡眠障碍患病率；（ii）与健康成人相比，COPD中的GSAQ得分是否高；（iii）慢性阻塞性肺病患者失眠，阻塞性睡眠呼吸暂停（OSA），不安腿综合征（RLS）和抑郁症的患病率；（iv）GSAQ的敏感性和特异性。
方法：这是一项前瞻性病例对照研究，其中将GSAQ应用于100名稳定的COPD和50名健康个体。根据诊断标准和多导睡眠图进一步确认了COPD中睡眠障碍的存在。
结果： 68％的COPD患者中GSAQ阳性，而相匹配的健康成人为16％（P <0.001）。在66名COPD患者中确认了睡眠障碍。分别在39、13、30、22和31位患者中发现失眠，OSA，RLS，抑郁/焦虑以及两种或多种疾病的重叠。GSAQ对COPD睡眠障碍的总体敏感性/特异性分别为90.9％/ 70.58％。GSAQ对失眠，OSA，RLS和焦虑/抑郁的敏感性/特异性分别为87/75％，77/67％，90/80％和91/65％。
结论： COPD患者的睡眠障碍明显较高。GSAQ是检测COPD中睡眠不足的良好筛查工具。慢性阻塞性肺病常见两种或两种以上睡眠障碍。