Parkinson’s disease (PD) is the second most common neurodegenerative disease. Crocetin, derived from saffron, exerts multiple pharmacological properties, such as anti-inflammatory, antioxidant, antifatigue, and anticancer effects. However, the effect of crocetin on PD remains unclear. In this study, we designed experiments to investigate the effect of crocetin against MPTP-induced PD models and the underlying mechanisms. Our results showed that crocetin treatment attenuates MPTP-induced motor deficits and protects dopaminergic neurons. Both in vivo and in vitro experiments demonstrated that crocetin treatment decreased the expression of inflammatory associated genes and inflammatory cytokines. Furthermore, crocetin treatment protected mitochondrial functions against MPP+ induced damage by regulating the mPTP (mitochondrial permeability transition pore) viability in the interaction of ANT (adenine nucleotide translocase) and Cyp D (Cyclophilin D) dependent manner. Therefore, our results demonstrate that crocetin has therapeutic potential in Parkinson’s disease.

中文翻译：

---

Crocetin通过改善线粒体功能缓解MPTP诱发的帕金森氏病模型中的炎症

帕金森氏病（PD）是第二常见的神经退行性疾病。藏红花中的藏红花素具有多种药理特性，例如抗炎，抗氧化，抗疲劳和抗癌作用。然而，藏红花对PD的作用仍不清楚。在这项研究中，我们设计了实验来研究番红花素对MPTP诱导的PD模型的影响及其潜在机制。我们的研究结果表明，藏红花苷治疗可减轻MPTP引起的运动功能障碍并保护多巴胺能神经元。两者在体内和体外实验表明，大黄素处理可以降低炎症相关基因和炎症细胞因子的表达。此外，藏红花素处理通过调节ANT（腺嘌呤核苷酸转运酶）和Cyp D（Cyclophilin D）依赖性相互作用中的mPTP（线粒体通透性过渡孔）活力来保护线粒体功能免受MPP +诱导的损伤。因此，我们的结果表明藏红花素在帕金森氏病中具有治疗潜力。