Using data from the COMPASS-ND study we investigated associations between hearing loss and hippocampal volume as well as cortical thickness in older adults with subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer's dementia (AD). SCD participants with greater pure-tone HL exhibited lower hippocampal volume, but more cortical thickness in the left superior temporal gyrus and right pars opercularis. Greater speech-in-noise reception thresholds were associated with lower cortical thickness bilaterally across much of the cortex in AD. The AD group also showed a trend towards worse speech-in-noise thresholds compared to the SCD group.

中文翻译：

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听力损失与有阿尔茨海默病风险和患有阿尔茨海默病的老年人的灰质差异有关

使用 COMPASS-ND 研究的数据，我们调查了患有主观认知能力下降 (SCD)、轻度认知障碍 (MCI) 和阿尔茨海默氏症 (AD) 的老年人的听力损失与海马体积以及皮质厚度之间的关联。具有更大纯音 HL 的 SCD 参与者表现出较低的海马体积，但左侧颞上回和右侧鳃盖部的皮质厚度更大。在 AD 中，较大的噪声接收阈值与较低的双侧皮层厚度相关。与 SCD 组相比，AD 组还显示出噪声中语音阈值更差的趋势。