Gold Nanoclusters-Decorated Zeolitic Imidazolate Frameworks with Reactive Oxygen Species Generation for Photoenhanced Antibacterial Study,Bioconjugate Chemistry

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Gold Nanoclusters-Decorated Zeolitic Imidazolate Frameworks with Reactive Oxygen Species Generation for Photoenhanced Antibacterial Study
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2020-10-11 , DOI: 10.1021/acs.bioconjchem.0c00485
Shuhan Hui ₁ , Qiqi Liu ₁ , Zhenzhen Huang ₁ , Jun Yang ₁ , Yanmei Liu ₁ , Shan Jiang ₁

Affiliation

The serious threat of antibiotic-resistant bacterial infections has brought an urgent need for the development of new antibacterial nanomaterials. We encapsulate glutathione (GSH)-protected gold nanoclusters (AuNCs) in zeolitic imidazolate frameworks-8 (ZIF-8) and present their potential in antibacterial capabilities. Under white light irradiation, AuNCs-embedded ZIF-8 nanocomposites show assembly-enhanced emission and reactive oxygen species (ROS) generation. AuNCs@ZIF-8 exhibit almost complete inactivation of bacterial growth within 60 min of light irradiation. Scanning electron microscopic results show that AuNCs@ZIF-8 nanocomposites are captured by bacterial cells, and the leakage of alkaline phosphatase and nucleotides from bacteria demonstrate that the photoinduced ROS can easily destroy the bacterial surface and totally kill the bacteria. Herein, our antibacterial nanocomposites have photoenhanced bactericidal capability and show promising applications for sterilization.

中文翻译：

金纳米簇装饰的沸石咪唑盐骨架与活性氧的生成，用于光增强抗菌研究

抗生素抗性细菌感染的严重威胁已经迫切需要开发新的抗菌纳米材料。我们将谷胱甘肽（GSH）保护的金纳米簇（AuNCs）封装在沸石咪唑酯骨架8（ZIF-8）中，并展示它们在抗菌能力方面的潜力。在白光照射下，嵌入AuNCs的ZIF-8纳米复合材料显示出增强的发射和活性氧（ROS）生成。AuNCs @ ZIF-8在光照60分钟内几乎完全灭活了细菌。扫描电子显微镜结果表明，AuNCs @ ZIF-8纳米复合物被细菌细胞捕获，碱性磷酸酶和核苷酸从细菌中的泄漏表明光诱导的ROS可以轻易破坏细菌表面并完全杀死细菌。

更新日期：2020-10-11

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