The developing field of bio-nanotechnology aims to advance colloidal research via the introduction of multifunctional nanoparticles to augment the dermal effectiveness of active substances. Self-emulsifying drug delivery systems (SEDDS)—isotropic mixtures of oils, surfactants, solvents and co-solvents or surfactants—are attracting interest in the cosmeceutical field. As part of this study, SEDDS systems containing vitamin C or vitamin E and curcumin were developed, whereby the bioavailability of the active compounds increased by enhancing their permeability to deeper layers of the skin. A composition consisting of 50% surfactin from Bacillus subtilis, 30% Transcutol and 20% oil phase was designed to encapsulate the active substances, i.e., vitamin C or vitamin E and curcumin, contained in the oil phase. The developed carriers were characterized by average particle sizes of 69–183 nm. The formulations with the vitamins were found to be physically and chemically stable for 6 months. Transdermal tests were carried out, showing that the carriers enable the transport of active substances deep into the skin, stopping at the dermis border. The formulations with vitamin C and vitamin E reduced the discoloration, the vascular lesions, and the depth of the wrinkles on the tested skin, which can be useful in cosmetics in the treatment of problem skin, including capillary and sensitive skin.

中文翻译：

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由枯草芽孢杆菌安全表面活性剂稳定的纳米乳液作为多功能、定制设计的智能输送系统


生物纳米技术的发展领域旨在通过引入多功能纳米颗粒来增强活性物质的皮肤功效，从而推进胶体研究。自乳化药物输送系统 (SEDDS)——油、表面活性剂、溶剂和助溶剂或表面活性剂的各向同性混合物——正在引起药妆领域的兴趣。作为这项研究的一部分，开发了含有维生素 C 或维生素 E 和姜黄素的 SEDDS 系统，通过增强活性化合物对皮肤更深层的渗透性，提高了活性化合物的生物利用度。设计由50％来自枯草芽孢杆菌的表面活性素、30％Transcutol和20％油相组成的组合物，以包封油相中所含的活性物质，即维生素C或维生素E和姜黄素。所开发的载体的平均粒径为 69-183 nm。含有维生素的配方被发现在 6 个月内物理和化学稳定。进行的透皮测试表明，载体能够将活性物质输送到皮肤深处，并在真皮边界停止。含有维生素 C 和维生素 E 的配方减少了测试皮肤的变色、血管病变和皱纹深度，这可用于治疗问题皮肤（包括毛细血管皮肤和敏感皮肤）的化妆品。