Nanoparticles have become a powerful tool in oncology not only as carrier of the highly toxic chemotherapeutic drugs but also as imaging contrast agents that provide valuable information about the state of the disease and its progression. The enhanced permeation and retention effect for loaded nanocarriers in tumors allow substantial improvement of selectivity and safety of anticancer nanomedicines. Additionally, the possibility to design stimuli-responsive nanocarriers able to release their payload in response to specific stimuli provide an excellent control on the administered dosage. The aim of this review is not to present a comprehensive revision of the different theranostic mesoporous silica nanoparticles (MSN) which have been published in the recent years but just to describe a few selected examples to offer a panoramic view to the reader about the suitability and effectiveness of these nanocarriers in the oncology field.

中文翻译：

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介孔二氧化硅纳米颗粒作为治疗诊断抗肿瘤纳米药物


纳米颗粒已成为肿瘤学的强大工具，不仅作为剧毒化疗药物的载体，而且作为成像造影剂，提供有关疾病状态及其进展的有价值的信息。负载纳米载体在肿瘤中增强的渗透和滞留效应可以显着提高抗癌纳米药物的选择性和安全性。此外，设计能够响应特定刺激释放其有效负载的刺激响应纳米载体的可能性提供了对给药剂量的良好控制。本综述的目的不是对近年来发表的不同治疗诊断介孔二氧化硅纳米颗粒（MSN）进行全面修订，而只是描述一些选定的例子，以便为读者提供有关其适用性和有效性的全景图。这些纳米载体在肿瘤学领域的有效性。