Bullous pemphigoid (BP) is the most frequent autoimmune subepidermal blistering disease provoked by autoantibodies directed against two hemidesmosomal proteins: BP180 and BP230. Its pathogenesis depends on the interaction between predisposing factors, such as human leukocyte antigen (HLA) genes, comorbidities, aging, and trigger factors. Several trigger factors, such as drugs, thermal or electrical burns, surgical procedures, trauma, ultraviolet irradiation, radiotherapy, chemical preparations, transplants, and infections may induce or exacerbate BP disease. Identification of predisposing and trigger factors can increase the understanding of BP pathogenesis. Furthermore, an accurate anamnesis focused on the recognition of a possible trigger factor can improve prognosis by promptly removing it.

中文翻译：

---

大疱性类天疱疮：触发因素和诱发因素

大疱性类天疱疮 (BP) 是最常见的自身免疫性表皮下水疱疾病，由针对两种半桥粒蛋白 BP180 和 BP230 的自身抗体引起。其发病机制取决于诱发因素之间的相互作用，例如人类白细胞抗原（HLA）基因、合并症、衰老和触发因素。药物、热或电烧伤、外科手术、创伤、紫外线照射、放射治疗、化学制剂、移植和感染等多种触发因素可能会诱发或加剧血压疾病。识别诱发因素和触发因素可以增加对 BP 发病机制的了解。此外，专注于识别可能的触发因素的准确病史可以通过及时消除它来改善预后。