l-Asparaginase Encapsulation into Asymmetric Permeable Polymersomes,ACS Macro Letters

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l-Asparaginase Encapsulation into Asymmetric Permeable Polymersomes
ACS Macro Letters ( IF 5.1 ) Pub Date : 2020-10-09 , DOI: 10.1021/acsmacrolett.0c00619
Cecilia Z. Bueno _{1,

2} , Alexsandra C. Apolinário _{1,

2,

3} , Aroa Duro-Castano ₂ , Alessandro Poma _{2,

4} , Adalberto Pessoa ₁ , Carlota O. Rangel-Yagui ₁ , Giuseppe Battaglia _{2,

5,

6}

Affiliation

This work reports, for the encapsulation of l-asparaginase, an anticancer enzyme into hybrid PMPC₂₅–PDPA₇₀/PEO₁₆–PBO₂₂ asymmetric polymersomes previously developed by our group, with loading capacities with over 800 molecules per vesicle. Enzyme-loaded polymersomes show permeability and capacity to hydrolyze l-asparagine, which is essential to cancer cells. The nanoreactors proposed in this work can be potentially used in further studies to develop novel therapeutic alternatives based on l-asparaginase.

中文翻译：

l-天冬酰胺酶包封到不对称的可渗透聚合物中

这项工作报告，为的封装升-asparaginase，抗癌酶进入混合PMPC ₂₅ -PDPA ₇₀ / PEO _16种-PbO ₂₂之前由我们的小组开发，与负载容量超过800的非对称聚合物囊泡每分子囊泡。负载酶的聚合物囊泡显示渗透性和水解l-天冬酰胺的能力，这对癌细胞至关重要。在这项工作中提出的纳米反应器可以潜在地用于进一步的研究中，以开发基于1-天冬酰胺酶的新型治疗替代品。

更新日期：2020-10-21

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