Abstract Syntheses of pyridazine derivatives of dibenzoazepine, starting from N-substituted-dibenzoazepines, are reported here for the first time. In the reaction sequence, N-substitute dibenzoazepine derivatives were synthesized and then, examined inverse electron demand Diels–Alder (IEDDA) reactions between N-substituted dibenzoazepine derivatives and tetrazines. While in some reactions, targeted products were obtained using phenyliodo-bis(trifluoroacetate) (PIFA), in other reactions, they were obtained directly with tetrazines which also behaved as the oxidizing agent. Structures of these compounds were fully characterized by NMR, IR, and HRMS spectroscopic techniques. Graphical Abstract

中文翻译：

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N-取代二苯并氮杂-哒嗪衍生物作为潜在神经活性药物的合成

摘要 本文首次报道了以 N-取代的二苯并氮杂为原料合成二苯并氮杂的哒嗪衍生物。在反应序列中，合成了 N-取代的二苯并氮杂衍生物，然后检查了 N-取代的二苯并氮杂衍生物和四嗪之间的逆电子需求 Diels-Alder (IEDDA) 反应。虽然在某些反应中，目标产物是使用苯基碘-双（三氟乙酸盐）（PIFA）获得的，但在其他反应中，它们是直接使用四嗪作为氧化剂获得的。这些化合物的结构通过 NMR、IR 和 HRMS 光谱技术进行了充分表征。图形概要