Abstract

The present study depicts the formation and characterization of electrospun nanofibrous mat generated from the mixture of poly (vinyl alcohol) (PVA) and Mikania Micrantha extract to incorporate the inherent medicinal properties of this natural herb for biomedical application. The nano mats were produced by the solution electrospinning technique with different mixing ratio under the optimum electrospinning conditions. The morphological structure, bonding behavior and moisture management properties of the developed mats were investigated by SEM, FTIR and moisture management test (AATCC 195-2009) respectively. The SEM analysis showed the homogenous and smooth fiber formation with average diameter of 75.85 ± 21.70 nm and the presence of compounds of PVA and Mikania Micrantha extracts were confirmed in by FTIR characteristic peaks at particular wave number. Results of moisture management test revealed that the developed nanomat exhibited better moisture management properties as the ratio of leaf extract is increased in comparison with PVA nanofiber alone. Aside from this, the bacterial resistance was evaluated against Gram-positive (S.aureus- ATCC 6538) bacteria using disc diffusion method for the sample developed at maximum mixing ratio of Mikania Micrantha extract (80%) which shows the formation of inhibition zone up to 12 mm due to the antibacterial constituents of Mikania Micrantha extract. Thus, the developed mats have a great potential to be used as biodegradable, biobased and antibacterial one in biomedical applications.

摘要

本研究描述了由聚乙烯醇 (PVA) 和薇甘菊提取物的混合物产生的静电纺纳米纤维垫的形成和表征，以结合这种天然草药的固有药用特性，用于生物医学应用。在最佳静电纺丝条件下，采用不同混合比的溶液静电纺丝技术制备纳米垫。开发的垫子的形态结构、粘合行为和水分管理性能分别通过 SEM、FTIR 和水分管理测试 (AATCC 195-2009) 进行了研究。SEM 分析表明纤维形成均匀光滑，平均直径为 75.85 ± 21.70 nm，并存在 PVA 和薇甘菊化合物通过特定波数处的 FTIR 特征峰确认提取物。水分管理测试结果表明，与单独的 PVA 纳米纤维相比，随着叶子提取物的比例增加，开发的纳米垫表现出更好的水分管理特性。除此之外，使用圆盘扩散法对在最大混合比例的薇甘菊提取物（80%）下开发的样品评估了对革兰氏阳性（金黄色葡萄球菌-ATCC 6538）细菌的耐药性，表明抑制带的形成由于Mikania Micrantha提取物的抗菌成分，可达到 12 毫米。因此，开发的垫子在生物医学应用中作为可生物降解的、生物基的和抗菌的垫子具有很大的潜力。