Abstract

Hypertension is defined as the persistence of elevated blood pressure in the circulation system. The renin-angiotensin-aldosterone system is a major modulator of blood pressure. Among the risk factors of cardiovascular disease, hypertension is the most preventable and treatable, with drugs such as ACE inhibitors. Many ACE inhibitors are known to have undesirable side effects and hence, natural alternatives are being sought. Dietary polyphenols, particularly ellagitannins, are derived from plant products and are known to exhibit a variety of bioactivities. Geraniin, an ellagitannin has been shown to have antihypertensive activity in animal experiments. It is speculated that the metabolites of geraniin are responsible for its ACE inhibitory activity. We have performed in vitro ACE inhibition and in silico studies with geraniin and its metabolites (ellagic acid, urolithins). Our studies confirm that ellagic acid exhibited similar inhibitory potential to ACE as the positive control captopril.

摘要

高血压被定义为循环系统中持续升高的血压。肾素-血管紧张素-醛固酮系统是血压的主要调节剂。在心血管疾病的危险因素中，高血压是最可预防和治疗的，有ACE抑制剂等药物。已知许多 ACE 抑制剂具有不良副作用，因此正在寻找天然替代品。膳食多酚，尤其是鞣花单宁，来源于植物产品，并且已知具有多种生物活性。Geraniin，一种鞣花单宁，在动物实验中已被证明具有抗高血压活性。据推测，香叶苷的代谢物是其 ACE 抑制活性的原因。我们已经进行了体外ACE 抑制和用香叶素及其代谢物（鞣花酸、尿石素）进行的计算机模拟研究。我们的研究证实，与阳性对照卡托普利一样，鞣花酸对 ACE 具有相似的抑制潜力。