Natural Product Research ( IF 1.9 ) Pub Date : 2020-10-09 , DOI: 10.1080/14786419.2020.1828405 Van-Muoi Bui 1 , Thuc-Huy Duong 2 , Warinthorn Chavasiri 3 , Kim-Phi-Phung Nguyen 1 , Bui-Linh-Chi Huynh 4
Abstract
Chemical investigation of the lichen Usnea ceratina Arch led to the isolation of five depsidones, including one new compound ceratinalone (1) along with four known compounds bailesidone (2), stictic acid (3), 8′-O-methylstictic acid (4) and 8′-O-ethylstictic acid (5). The structures were determined by analysis of their MS and NMR data as well as by comparison with literature values. Compounds 1 and 4 were evaluated the cytotoxic activity against HeLa (human epithelial carcinoma), NCI-H460 (human lung cancer), HepG2 (liver hepatocellular carcinoma), and MCF-7 (human breast cancer) cell lines, showing the moderate activity.
中文翻译:
来自地衣 Usnea ceratina Arch 的新 depsidone
摘要
对地衣Usnea ceratina Arch 的化学研究导致分离出五种地塞酮,包括一种新化合物角西酮(1)以及四种已知化合物百利西酮(2)、硬脂酸(3)、8'- O-甲基硬脂酸(4)和8'- O-乙基stic酸(5)。通过分析它们的 MS 和 NMR 数据以及通过与文献值的比较来确定结构。化合物1和4评估了对 HeLa(人上皮癌)、NCI-H460(人肺癌)、HepG2(肝细胞癌)和 MCF-7(人乳腺癌)细胞系的细胞毒活性,显示出中等活性。