Novel pranoprofen‐poly(ε‐caprolactone) conjugates: microwave‐assisted synthesis and structural characterization,Polymer International

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Novel pranoprofen‐poly(ε‐caprolactone) conjugates: microwave‐assisted synthesis and structural characterization
Polymer International ( IF 2.9 ) Pub Date : 2020-10-11 , DOI: 10.1002/pi.6141
Giuseppe Impallomeni ₁ , Placido Giuseppe Mineo _{1,

2} , Fabiana Vento ₂ , Alberto Ballistreri ₃

Affiliation

Biodegradable polymers are used in many biomedical devices, such as implants, cellular scaffolds and drug delivery systems. To improve drug delivery capability and to reduce systemic toxicity, the interest in polymer–drug conjugates has increased remarkably. With this aim, pranoprofen (PPF) (an effective non‐steroidal anti‐inflammatory drug used mainly in ophthalmology) was conjugated to poly(ε‐caprolactone) (PCL) via microwave‐assisted transesterification, acid‐catalyzed by p‐toluenesulfonic acid. The products obtained were characterized by NMR, matrix assisted laser desorption ionization time of flight mass spectrometry, gel permeation chromatography (which gave proof of the covalent link between PPF and PCL) and thermal analyses. The conjugates were found to contain up to 4.3% w/w of PPF and had molecular weights ranging from 5 to 12 kDa. © 2020 Society of Industrial Chemistry

中文翻译：

新型pranoprofen-聚（ε-己内酯）偶联物：微波辅助合成和结构表征

可生物降解的聚合物被用于许多生物医学装置中，例如植入物，细胞支架和药物递送系统。为了提高药物传递能力并降低全身毒性，人们对聚合物-药物结合物的兴趣显着增加。为了这个目的，普拉洛芬（PPF）（主要用于眼科的有效非甾体类抗炎药）通过微波辅助酯交换缀合于聚（ε -己内酯）（PCL），由酸催化的p甲苯磺酸。所得产物通过NMR，基质辅助激光解吸电离飞行时间质谱，凝胶渗透色谱法（提供PPF和PCL之间的共价键的证据）和热分析进行表征。发现缀合物包含高达4.3％w / w的PPF，并且分子量为5至12kDa。©2020工业化学学会

更新日期：2020-10-11

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