Cyclic dipeptides: Biological activities and self‐assembled materials,Peptide Science

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Cyclic dipeptides: Biological activities and self‐assembled materials
Peptide Science ( IF 1.5 ) Pub Date : 2020-10-10 , DOI: 10.1002/pep2.24202
Kaili Zhao _{1,

2} , Ruirui Xing _{1,

2} , Xuehai Yan _{1,

2}

Affiliation

Cyclic dipeptides (CDPs) are the smallest cyclic peptides containing 2,5‐diketopiperazine rings. CDPs have advantages of structures and properties, including excellent hydrogen‐bonding‐forming ability (two hydrogen bonding acceptors and two hydrogen bonding donors), structural rigidity, and enzymatic stability, which make CDPs potential candidates as core scaffolds for drug discovery and building blocks for self‐assembly. In this review, we focus on distinctive bioactivities of CDPs, such as antitumor, antimicrobial, antivirus and antioxidant, and self‐assembly properties of CDPs and their derivatives. Emphasis will be placed on the thermodynamics and kinetics CDPs self‐assembly and applications of self‐assembled materials. This review provides insight into the development of CDPs and their corresponding assembled materials as drug delivery carriers and optoelectronic materials.

中文翻译：

环状二肽：生物活性和自组装材料

环二肽（CDP）是包含2,5-二酮哌嗪环的最小环肽。CDP具有结构和性能方面的优势，包括出色的氢键形成能力（两个氢键受体和两个氢键供体），结构刚性和酶稳定性，这使CDP成为潜在的候选药物，成为药物发现和构建的基础材料。自组装。在这篇综述中，我们关注CDP的独特生物活性，例如抗肿瘤，抗微生物，抗病毒和抗氧化剂，以及CDP及其衍生物的自组装特性。重点将放在热力学和动力学CDP的自组装以及自组装材料的应用上。

更新日期：2020-10-10

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