hnRNPU Functions as a Novel Therapeutic Target of c‐Myc in the Progression of Hepatocellular Carcinoma,FEBS Letters

当前位置： X-MOL 学术 › FEBS Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

hnRNPU Functions as a Novel Therapeutic Target of c‐Myc in the Progression of Hepatocellular Carcinoma
FEBS Letters ( IF 3.0 ) Pub Date : 2020-11-07 , DOI: 10.1002/1873-3468.13943
Biao Zhang _{1,

2} , Hai-Yang Wang _{1,

2} , De-Xi Zhao ₃ , Dong-Xing Wang _{1,

2} , Quan Zeng _{1,

2} , Jia-Fei Xi _{1,

2} , Xue Nan _{1,

2} , Li-Juan He _{1,

2} , Jun-Nian Zhou _{1,

2,

4} , Xue-Tao Pei _{1,

2} , Wen Yue _{1,

2}

Affiliation

Hepatocellular carcinoma (HCC) is the most common liver cancer with high mortality. Here, we found that hnRNPU is overexpressed in HCC tissues and is correlated with the poor prognosis of HCC patients. Besides, hnRNPU is of high significance in regulating the proliferation, apoptosis, self-renewal and tumorigenic potential of HCC cells. Mechanismly, c-Myc regulates hnRNPU expression at the transcriptional level, and meanwhile hnRNPU stabilizes the mRNA of c-MYC. We found that the hnRNPU and c-Myc regulatory loop exerts a synergistic effect on the proliferation and self-renewal of HCC, and promotes the HCC progression. Taken together, hnRNPU functions as a novel transcriptional target of c-Myc and promotes HCC progression, which may become a promising target for the treatment of c-Myc-driven HCC.

中文翻译：

hnRNPU 作为 c-Myc 在肝细胞癌进展中的新治疗靶点

肝细胞癌（HCC）是最常见的肝癌，死亡率很高。在这里，我们发现hnRNPU在HCC组织中过度表达，并且与HCC患者的不良预后相关。此外，hnRNPU在调节HCC细胞的增殖、凋亡、自我更新和致瘤潜力方面具有重要意义。从机制上来说，c-Myc在转录水平上调节hnRNPU的表达，同时hnRNPU稳定c-MYC的mRNA。我们发现hnRNPU和c-Myc调节环对HCC的增殖和自我更新发挥协同作用，促进HCC进展。综上所述，hnRNPU 作为 c-Myc 的新型转录靶点发挥作用，促进 HCC 进展，这可能成为治疗 c-Myc 驱动的 HCC 的有希望的靶点。

更新日期：2020-11-07

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11