Drosophila insulin‐like peptides: from expression to functions – a review,Entomologia Experimentalis et Applicata

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Drosophila insulin‐like peptides: from expression to functions – a review
Entomologia Experimentalis et Applicata ( IF 1.4 ) Pub Date : 2020-10-08 , DOI: 10.1111/eea.12981
Uliana Semaniuk ₁ , Veronika Piskovatska ₂ , Olha Strilbytska ₁ , Tetiana Strutynska ₁ , Nadia Burdyliuk ₁ , Alexander Vaiserman ₃ , Volodymyr Bubalo ₄ , Kenneth B. Storey ₅ , Oleh Lushchak ₁

Affiliation

Insulin‐like peptides (ILPs) belong to the insulin superfamily and act as hormones, neuromediators, and growth factors during the post‐embryonic life‐cycle stages of insects. These peptides are encoded by different genes in various species. In the genus Drosophila, eight peptides are known, seven of which are likely to bind the Drosophila insulin receptor, whereas DILP8 is a known ligand of the Lgr3 receptor. Binding of DILPs 1‐7 to receptors leads to activation of intracellular proteins related to the conserved insulin/IGF (insulin‐like growth factors) signaling pathway. The insulin pathway acts within a complex physiological regulatory network involved in the coordination of development, growth, behavior, metabolism, lifespan, and cognitive functions in insects. The current review summarizes recent data about the structure and function of ILPs in fruit flies. The role of environmental factors and genetic manipulations in modulating the functions of DILPs and their association with lifespan and metabolism of Drosophila are assessed. Further investigation and identification of pharmacological or biotechnological interventions that may decrease insulin/IGF signaling could be a highly promising approach for extension of human health span and longevity.

中文翻译：

果蝇胰岛素样肽：从表达到功能–综述

胰岛素样肽（ILPs）属于胰岛素超家族，在昆虫的胚胎后生命周期阶段充当激素，神经介质和生长因子。这些肽由各种物种中的不同基因编码。在果蝇属中，已知八种肽，其中七种可能与果蝇结合胰岛素受体，而DILP8是Lgr3受体的已知配体。DILP 1-7与受体的结合会导致与保守的胰岛素/ IGF（胰岛素样生长因子）信号传导途径相关的细胞内蛋白质活化。胰岛素途径在复杂的生理调节网络内起作用，参与协调昆虫的发育，生长，行为，新陈代谢，寿命和认知功能。本综述总结了有关果蝇中ILP的结构和功能的最新数据。环境因素和遗传操纵在调节DILPs功能中的作用及其与果蝇的寿命和代谢的关系被评估。进一步研究和鉴定可能降低胰岛素/ IGF信号传导的药理或生物技术干预措施，可能是延长人类健康寿命和延长寿命的极有前途的方法。

更新日期：2020-10-08

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