当前位置：
X-MOL 学术
›
STEM CELLS
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Stem cell contributions to cementoblast differentiation in healthy periodontal ligament and periodontitis
STEM CELLS ( IF 4.0 ) Pub Date : 2020-10-10 , DOI: 10.1002/stem.3288 Jing Zhao 1 , Louis Faure 2 , Igor Adameyko 2 , Paul T Sharpe 1
STEM CELLS ( IF 4.0 ) Pub Date : 2020-10-10 , DOI: 10.1002/stem.3288 Jing Zhao 1 , Louis Faure 2 , Igor Adameyko 2 , Paul T Sharpe 1
Affiliation
|
Loss of tissue attachment as a consequence of bacterial infection and inflammation represents the main therapeutic target for the treatment of periodontitis. Cementoblasts, the cells that produce the mineralized tissue, cementum, that is responsible for connecting the soft periodontal tissue to the tooth, are a key cell type for maintaining/restoring tissue attachment following disease. Here, we identify two distinct stem cell populations that contribute to cementoblast differentiation at different times. During postnatal development, cementoblasts are formed from perivascular‐derived cells expressing CD90 and perivascular‐associated cells that express Axin2. During adult homeostasis, only Wnt‐responsive Axin2+ cells form cementoblasts but following experimental induction of periodontal disease, CD90+ cells become the main source of cementoblasts. We thus show that different populations of resident stem cells are mobilized at different times and during disease to generate precursors for cementoblast differentiation and thus provide an insight into the targeting cells resident cells for novel therapeutic approaches. The differentiation of these stem cells into cementoblasts is however inhibited by bacterial products such as lipopolysaccharides, emphasizing that regeneration of periodontal ligament soft tissue and restoration of attachment will require a multipronged approach.
中文翻译：
干细胞对健康牙周膜和牙周炎中成牙骨质细胞分化的贡献
细菌感染和炎症导致的组织附着丧失是牙周炎治疗的主要治疗目标。成牙骨质细胞是产生矿化组织、牙骨质的细胞，负责将软牙周组织连接到牙齿，是疾病后维持/恢复组织附着的关键细胞类型。在这里，我们鉴定了两种不同的干细胞群，它们在不同时间有助于成牙骨质细胞分化。在出生后发育过程中，成牙骨质细胞由表达 CD90 的血管周围衍生细胞和表达 Axin2 的血管周围相关细胞形成。在成人稳态期间，只有 Wnt 反应性 Axin2+ 细胞形成成牙骨质细胞，但在牙周病的实验诱导后，CD90+ 细胞成为成牙骨质细胞的主要来源。因此，我们表明，不同的常驻干细胞群在不同时间和疾病期间被动员，产生成牙骨质细胞分化的前体，从而为新的治疗方法提供了对靶向细胞常驻细胞的深入了解。然而，这些干细胞向成牙骨质细胞的分化受到脂多糖等细菌产物的抑制，这强调牙周膜软组织的再生和附着的恢复需要多管齐下的方法。
更新日期：2020-10-10
中文翻译：
干细胞对健康牙周膜和牙周炎中成牙骨质细胞分化的贡献
细菌感染和炎症导致的组织附着丧失是牙周炎治疗的主要治疗目标。成牙骨质细胞是产生矿化组织、牙骨质的细胞，负责将软牙周组织连接到牙齿，是疾病后维持/恢复组织附着的关键细胞类型。在这里，我们鉴定了两种不同的干细胞群，它们在不同时间有助于成牙骨质细胞分化。在出生后发育过程中，成牙骨质细胞由表达 CD90 的血管周围衍生细胞和表达 Axin2 的血管周围相关细胞形成。在成人稳态期间，只有 Wnt 反应性 Axin2+ 细胞形成成牙骨质细胞，但在牙周病的实验诱导后，CD90+ 细胞成为成牙骨质细胞的主要来源。因此，我们表明，不同的常驻干细胞群在不同时间和疾病期间被动员，产生成牙骨质细胞分化的前体，从而为新的治疗方法提供了对靶向细胞常驻细胞的深入了解。然而，这些干细胞向成牙骨质细胞的分化受到脂多糖等细菌产物的抑制，这强调牙周膜软组织的再生和附着的恢复需要多管齐下的方法。
京公网安备 11010802027423号