Zinc provides neuroprotection by regulating NLRP3 inflammasome through autophagy and ubiquitination in a spinal contusion injury model,CNS Neuroscience & Therapeutics

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Zinc provides neuroprotection by regulating NLRP3 inflammasome through autophagy and ubiquitination in a spinal contusion injury model
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2020-10-09 , DOI: 10.1111/cns.13460
Jia-Quan Lin ₁ , He Tian ₂ , Xiao-Guang Zhao ₃ , Sen Lin ₁ , Dao-Yong Li ₁ , Yuan-Ye Liu ₁ , Chang Xu ₁ , Xi-Fan Mei ₁

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Spinal cord injury (SCI) is a serious disabling injury worldwide, and the excessive inflammatory response it causes plays an important role in secondary injury. Regulating the inflammatory response can be a potential therapeutic strategy for improving the prognosis of SCI. Zinc has been demonstrated to have a neuroprotective effect in experimental spinal cord injury models. In this study, we aimed to explore the neuroprotective effect of zinc through the suppression of the NLRP3 inflammasome.

中文翻译：

在脊髓挫伤模型中，锌通过自噬和泛素化调节 NLRP3 炎性体来提供神经保护

脊髓损伤（SCI）是世界范围内一种严重的致残性损伤，其引起的过度炎症反应在继发性损伤中起重要作用。调节炎症反应可能是改善 SCI 预后的潜在治疗策略。锌已被证明在实验性脊髓损伤模型中具有神经保护作用。在这项研究中，我们旨在通过抑制 NLRP3 炎性体来探索锌的神经保护作用。

更新日期：2020-10-09

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