Progenitor cell therapy for acquired pediatric nervous system injury: Traumatic brain injury and acquired sensorineural hearing loss,STEM CELLS Translational Medicine

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Progenitor cell therapy for acquired pediatric nervous system injury: Traumatic brain injury and acquired sensorineural hearing loss
STEM CELLS Translational Medicine ( IF 5.4 ) Pub Date : 2020-10-09 , DOI: 10.1002/sctm.20-0026
James E Baumgartner _{1,

2} , Linda S Baumgartner ₃ , Michael E Baumgartner ₄ , Ernest J Moore ₅ , Steven A Messina ₆ , Michael D Seidman _{7,

8} , David R Shook ₁

Affiliation

While cell therapies hold remarkable promise for replacing injured cells and repairing damaged tissues, cell replacement is not the only means by which these therapies can achieve therapeutic effect. For example, recent publications show that treatment with varieties of adult, multipotent stem cells can improve outcomes in patients with neurological conditions such as traumatic brain injury and hearing loss without directly replacing damaged or lost cells. As the immune system plays a central role in injury response and tissue repair, we here suggest that multipotent stem cell therapies achieve therapeutic effect by altering the immune response to injury, thereby limiting damage due to inflammation and possibly promoting repair. These findings argue for a broader understanding of the mechanisms by which cell therapies can benefit patients.

中文翻译：

祖细胞疗法治疗获得性小儿神经系统损伤：创伤性脑损伤和获得性感音神经性听力损失

虽然细胞疗法在替代受损细胞和修复受损组织方面具有显着的前景，但细胞替代并不是这些疗法实现治疗效果的唯一手段。例如，最近的出版物表明，使用各种成体多能干细胞治疗可以改善患有神经系统疾病（例如创伤性脑损伤和听力损失）的患者的预后，而无需直接替换受损或丢失的细胞。由于免疫系统在损伤反应和组织修复中发挥着核心作用，因此我们建议多能干细胞疗法通过改变对损伤的免疫反应来达到治疗效果，从而限制炎症引起的损伤并可能促进修复。这些发现有助于更广泛地了解细胞疗法使患者受益的机制。

更新日期：2020-10-09

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