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Derivatization increases mosquito larvicidal activity of the sesquiterpene lactone parthenin isolated from the invasive weed Parthenium hysterophorus
Pest Management Science ( IF 3.8 ) Pub Date : 2020-10-09 , DOI: 10.1002/ps.6131 Trizah K Milugo 1, 2 , David P Tchouassi 1 , Reginald A Kavishe 2 , Rhoel R Dinglasan 3 , Baldwyn Torto 1
Pest Management Science ( IF 3.8 ) Pub Date : 2020-10-09 , DOI: 10.1002/ps.6131 Trizah K Milugo 1, 2 , David P Tchouassi 1 , Reginald A Kavishe 2 , Rhoel R Dinglasan 3 , Baldwyn Torto 1
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Extracts of the invasive weed Parthenium hysterophorus (Asteraceae) have been shown to possess larvicidal activity against a wide range of disease vectors. However, the phytochemicals responsible for the larvicidal activity from this plant remain unidentified. Here, we isolated the major sesquiterpene lactone, parthenin (1) from the plant and synthesized two derivatives [ethylene glycol (2) and azide (3) derivatives] targeting the α,β‐unsaturated carbonyl group, previously known to account for its biological activity such as toxicity towards cells and microorganism. All three compounds were screened for larvicidal activity against the African malaria vector Anopheles gambiae.
中文翻译：
衍生化增加了从侵入性杂草爬山Part分离的倍半萜内酯爬山hen的蚊幼虫活性
入侵性杂草爬山Part（Asteraceae）的提取物已显示出对多种疾病载体具有杀幼虫活性。然而，尚未确定负责这种植物幼虫活性的植物化学物质。在这里，我们从植物中分离出主要的倍半萜烯内酯，孤雌激素（1），并合成了针对α，β-不饱和羰基的两种衍生物[乙二醇（2）和叠氮化物（3）衍生物]，以前已知其生物学原因活性，例如对细胞和微生物的毒性。筛选了三种化合物对非洲疟疾冈比亚按蚊的杀幼虫活性。
更新日期：2020-10-09
中文翻译：
衍生化增加了从侵入性杂草爬山Part分离的倍半萜内酯爬山hen的蚊幼虫活性
入侵性杂草爬山Part（Asteraceae）的提取物已显示出对多种疾病载体具有杀幼虫活性。然而，尚未确定负责这种植物幼虫活性的植物化学物质。在这里，我们从植物中分离出主要的倍半萜烯内酯，孤雌激素（1），并合成了针对α，β-不饱和羰基的两种衍生物[乙二醇（2）和叠氮化物（3）衍生物]，以前已知其生物学原因活性，例如对细胞和微生物的毒性。筛选了三种化合物对非洲疟疾冈比亚按蚊的杀幼虫活性。
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