当前位置：
X-MOL 学术
›
J. Food Biochem.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
The impact of the co‐exposure of melanoma cells to chlorogenic acid and a moderate‐strength static magnetic field
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-10-08 , DOI: 10.1111/jfbc.13512 Magdalena Kimsa-Dudek 1 , Agata Krawczyk 1 , Agnieszka Synowiec-Wojtarowicz 1 , Sławomir Dudek 2 , Katarzyna Pawłowska-Góral 1
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-10-08 , DOI: 10.1111/jfbc.13512 Magdalena Kimsa-Dudek 1 , Agata Krawczyk 1 , Agnieszka Synowiec-Wojtarowicz 1 , Sławomir Dudek 2 , Katarzyna Pawłowska-Góral 1
Affiliation
|
A static magnetic field (SMF) or the bioactive compounds that are found in foods are potential agents that can be used to support cancer therapy. Therefore, the aim of our study was to assess the impact of the SMF that are induced by neodymium magnets on the culture growth and antioxidant status of melanoma cells that had been treated with chlorogenic acid (CGA). The melanoma cells, the control and those that had been treated with CGA, were put in special magnetic test chambers that generated a 0.7 T magnetic field. The mRNA levels of the antioxidant enzymes were analyzed using RT‐qPCR. The activity of SOD, GPx, and CAT was measured in the cell lysates. While the expression and activity of the antioxidant enzymes was inhibited relative to the untreated cells as a result of the CGA treatment (1 mmol/L), it was not after the CGA treatment in combination with an SMF. The demonstrated cytotoxicity of CGA (1 mmol/L) and its inhibition of the antioxidant enzymes suggests the usefulness of phenolic compounds as a supporting pharmacological treatment for melanoma.
中文翻译：
黑色素瘤细胞与绿原酸和中等强度静磁场的共同暴露的影响
食物中发现的静磁场（SMF）或生物活性化合物是可用于支持癌症治疗的潜在药物。因此，我们的研究目的是评估钕磁铁诱导的SMF对经过绿原酸（CGA）处理的黑素瘤细胞的培养生长和抗氧化状态的影响。将黑色素瘤细胞，对照和经CGA处理的细胞放入产生0.7 T磁场的特殊磁性测试室中。使用RT-qPCR分析抗氧化酶的mRNA水平。在细胞裂解物中测量了SOD，GPx和CAT的活性。由于CGA处理（1 mmol / L），相对于未处理的细胞，抗氧化酶的表达和活性受到抑制，它不是经过CGA与SMF结合治疗后的结果。CGA（1 mmol / L）的细胞毒性及其对抗氧化酶的抑制作用表明，酚类化合物可作为辅助药物治疗黑色素瘤。
更新日期：2020-10-08
中文翻译：
黑色素瘤细胞与绿原酸和中等强度静磁场的共同暴露的影响
食物中发现的静磁场（SMF）或生物活性化合物是可用于支持癌症治疗的潜在药物。因此，我们的研究目的是评估钕磁铁诱导的SMF对经过绿原酸（CGA）处理的黑素瘤细胞的培养生长和抗氧化状态的影响。将黑色素瘤细胞，对照和经CGA处理的细胞放入产生0.7 T磁场的特殊磁性测试室中。使用RT-qPCR分析抗氧化酶的mRNA水平。在细胞裂解物中测量了SOD，GPx和CAT的活性。由于CGA处理（1 mmol / L），相对于未处理的细胞，抗氧化酶的表达和活性受到抑制，它不是经过CGA与SMF结合治疗后的结果。CGA（1 mmol / L）的细胞毒性及其对抗氧化酶的抑制作用表明，酚类化合物可作为辅助药物治疗黑色素瘤。
京公网安备 11010802027423号