Sorting nexins: A novel promising therapy target for cancerous/neoplastic diseases,Journal of Cellular Physiology

当前位置： X-MOL 学术 › J. Cell. Physiol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Sorting nexins: A novel promising therapy target for cancerous/neoplastic diseases
Journal of Cellular Physiology ( IF 4.5 ) Pub Date : 2020-10-09 , DOI: 10.1002/jcp.30093
Lu Yang _{1,

2} , Weihua Tan _{2,

3} , Xinzhi Yang _{1,

2} , Yong You ₄ , Jing Wang ₄ , Gebo Wen _{1,

2} , Jing Zhong _{1,

2}

Affiliation

Sorting nexins (SNXs) are a diverse group of cytoplasmic‐ and membrane‐associated phosphoinositide‐binding proteins containing the PX domain proteins. The function of SNX proteins in regulating intracellular protein trafficking consists of endocytosis, endosomal sorting, and endosomal signaling. Dysfunctions of SNX proteins are demonstrated to be involved in several cancerous/neoplastic diseases. Here, we review the accumulated evidence of the molecular structure and biological function of SNX proteins and discuss the regulatory role of SNX proteins in distinct cancerous/neoplastic diseases. SNX family proteins may be a valuable potential biomarker and therapeutic strategy for diagnostics and treatment of cancerous/neoplastic diseases.

中文翻译：

排序连接蛋白：癌症/肿瘤疾病的一种新的有前景的治疗靶点

分选连接蛋白 (SNX) 是一组不同的细胞质和膜相关的磷酸肌醇结合蛋白，含有 PX 结构域蛋白。 SNX 蛋白在调节细胞内蛋白运输中的功能包括内吞作用、内体分选和内体信号传导。 SNX 蛋白的功能障碍已被证明与多种癌症/肿瘤疾病有关。在这里，我们回顾了SNX蛋白分子结构和生物学功能的积累证据，并讨论了SNX蛋白在不同癌/肿瘤疾病中的调节作用。 SNX家族蛋白可能是诊断和治疗癌/肿瘤疾病的有价值的潜在生物标志物和治疗策略。

更新日期：2020-10-09

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11