Unique Vγ2Vδ2 (Vγ9Vδ2) T cells existing only in human and non‐human primates, account for the majority of circulating γδ T cells in human adults. Vγ2Vδ2 T cells are the sole γδ T‐cell subpopulation capable of recognizing the microbial (E)‐4‐hydroxy‐3‐methyl‐but‐2‐enyl pyrophosphate (HMBPP) produced by selected pathogens during infections. Recent seminal studies in non‐human primate models have demonstrated that the unique HMBPP‐specific Vγ2Vδ2 T cells are fast‐acting, multi‐functional, and protective during infections. This article reviews the recent seminal observations of Vγ2Vδ2 T cells in protective mechanisms against tuberculosis and other infections.

中文翻译：

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速效 γδ T 细胞亚群和针对感染的保护性免疫

独特的 Vγ2Vδ2 (Vγ9Vδ2) T 细胞仅存在于人和非人灵长类动物中，占成人循环 γδ T 细胞的大部分。Vγ2Vδ2 T 细胞是唯一能够识别由特定病原体在感染期间产生的微生物 (E)-4-羟基-3-甲基-丁-2-烯基焦磷酸 (HMBPP) 的 γδ T 细胞亚群。最近对非人类灵长类动物模型的开创性研究表明，独特的 HMBPP 特异性 Vγ2Vδ2 T 细胞在感染期间具有快速作用、多功能和保护作用。本文回顾了最近 Vγ2Vδ2 T 细胞在针对结核病和其他感染的保护机制中的开创性观察。