Protein tyrosine phosphatase receptor type Q in cerebrospinal fluid reflects ependymal cell dysfunction and is a potential biomarker for adult chronic hydrocephalus,European Journal of Neurology

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Protein tyrosine phosphatase receptor type Q in cerebrospinal fluid reflects ependymal cell dysfunction and is a potential biomarker for adult chronic hydrocephalus
European Journal of Neurology ( IF 4.5 ) Pub Date : 2020-10-09 , DOI: 10.1111/ene.14575
M Nakajima ₁ , T Rauramaa _{2,

3} , P M Mäkinen ₄ , M Hiltunen ₄ , S-K Herukka _{5,

6} , M Kokki ₇ , T Musialowicz ₇ , H-K Jyrkkänen _{8,

9} , N Danner _{8,

9} , A Junkkari _{8,

9} , A M Koivisto _{5,

6} , J E Jääskeläinen _{8,

9} , M Miyajima ₁ , I Ogino ₁ , A Furuta ₁₀ , C Akiba ₁ , K Kawamura ₁ , C Kamohara ₁ , H Sugano ₁ , Y Tange ₁ , K Karagiozov ₁ , V Leinonen _{8,

9,

11} , H Arai ₁

Affiliation

Department of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
Institute of Clinical Medicine－Pathology, University of Eastern, Finland.
Department of Pathology, Kuopio University Hospital, Kuopio, Finland.
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
Neurocentre, Neurology, Kuopio University Hospital, Kuopio, Finland.
Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland.
Institute of Clinical Medicine－Neurosurgery, University of Eastern, Finland.
Neurocentre, Neurosurgery, Kuopio University Hospital, Kuopio, Finland.
Department of Psychiatry and Behavioural Science, Juntendo University Faculty of Medicine, Tokyo, Japan.
Unit of Clinical Neuroscience, Neurosurgery, University of Oulu and Medical Research Centre, Oulu University Hospital, Oulu, Finland.

Protein tyrosine phosphatase receptor type Q (PTPRQ) was extracted from the cerebrospinal fluid (CSF) of patients with probable idiopathic normal‐pressure hydrocephalus (iNPH) by proteome analysis. We aimed to assess the feasibility of using CSF PTPRQ concentrations for the additional diagnostic criterion of iNPH in Japanese and Finnish populations.

中文翻译：

脑脊液中 Q 型蛋白酪氨酸磷酸酶受体反映室管膜细胞功能障碍，是成人慢性脑积水的潜在生物标志物

通过蛋白质组分析从可能患有特发性正常压力脑积水 (iNPH)的患者的脑脊液 (CSF) 中提取蛋白酪氨酸磷酸酶受体 Q (PTPRQ) 。我们旨在评估在日本和芬兰人群中使用 CSF PTPRQ 浓度作为 iNPH 附加诊断标准的可行性。

更新日期：2020-10-09

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