The Aeromonas salmonicida plasmidome: a model of modular evolution and genetic diversity,Annals of the New York Academy of Sciences

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The Aeromonas salmonicida plasmidome: a model of modular evolution and genetic diversity
Annals of the New York Academy of Sciences ( IF 4.1 ) Pub Date : 2020-10-10 , DOI: 10.1111/nyas.14503
Antony T. Vincent ₁ , Nava Hosseini _{2,

3,

4} , Steve J. Charette _{2,

3,

4}

Affiliation

High-throughput genomic sequencing has helped to reveal the plasmidome of Aeromonas salmonicida. This literature review provides an overview of A. salmonicida's rich plasmidome by presenting all the plasmids identified so far, addressing their biological importance and the functional links between them. The plasmids of A. salmonicida, especially those bearing antibiotic resistance genes, can provide clues about interactions of this species with other pathogens (animals and humans), as is the case for pRAS3-3432 and Chlamydia suis or pSN254b and Salmonella enterica. In addition to antibiotic resistance, plasmids play an important role in the virulence of A. salmonicida, particularly for the subspecies salmonicida and the plasmid pAsa5, which carries genes for the type-three secretion system, a virulence factor essential for the bacterium. The A. salmonicida plasmidome also has many cryptic plasmids with no known biological function, but which can be used for the acquisition of new genetic elements. Striking examples are pAsa7 and pAsaXII that provide, respectively, resistance to chloramphenicol and formaldehyde and are derivatives of cryptic pAsa2.

中文翻译：

杀鲑气单胞菌质粒组：模块化进化和遗传多样性的模型

高通量基因组测序有助于揭示杀鲑气单胞菌的质粒组。本文献综述通过介绍迄今为止鉴定的所有质粒，阐述了它们的生物学重要性和它们之间的功能联系，从而概述了杀鲑鱼的丰富质粒组。杀鲑鱼的质粒，尤其是那些带有抗生素抗性基因的质粒，可以提供有关该物种与其他病原体（动物和人类）相互作用的线索，例如 pRAS3-3432 和猪衣原体或 pSN254b 和沙门氏菌。除了抗生素抗性外，质粒在杀鲑鱼的毒力中也起着重要作用，特别是对于杀鲑鱼亚种和质粒 pAsa5，它携带第三型分泌系统的基因，这是细菌必不可少的毒力因子。A. 杀鲑鱼质粒组也有许多隐匿的质粒，没有已知的生物学功能，但可用于获取新的遗传元件。引人注目的例子是 pAsa7 和 pAsaXII，它们分别提供对氯霉素和甲醛的抗性，并且是隐匿的 pAsa2 的衍生物。

更新日期：2020-10-10

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