Spider silk is renowned for its impressive mechanical properties. It is one of the strongest known biomaterials, possessing mechanical properties that outmatch both steel and Kevlar. However, the farming of spiders for their silk is unfeasible. Consequently, production of recombinant spider silk proteins (spidroins) in more amenable hosts is an exciting field of research. For large-scale production to be viable, a heterologous silk production system that is both highly efficient and cost effective is essential. Genes encoding recombinant spidroin have been expressed in bacterial, yeast, insect, and mammalian cells, in addition to many other platforms. This review discusses the recent advances in exploiting an increasingly diverse range of host platforms in the heterologous production of recombinant spidroins.

蜘蛛丝以其令人印象深刻的机械性能而闻名。它是已知最强的生物材料之一，其机械性能优于钢和凯夫拉纤维。然而，为了蜘蛛丝而养殖蜘蛛是不可行的。因此，在更顺从的宿主中生产重组蜘蛛丝蛋白（蜘蛛丝）是一个令人兴奋的研究领域。为了实现大规模生产，高效且具有成本效益的异源丝生产系统至关重要。除了许多其他平台外，编码重组蛛丝蛋白的基因已在细菌、酵母、昆虫和哺乳动物细胞中表达。这篇综述讨论了在重组蜘蛛蛋白异源生产中利用日益多样化的宿主平台的最新进展。