The search for novel biologically active molecules has extended to the screening of organisms associated with less explored environments. In this sense, Oceans, which cover nearly the 67% of the globe, are interesting ecosystems characterized by a high biodiversity that is worth being explored. As such, marine microorganisms are highly interesting as promising sources of new bioactive compounds of potential value to humans. Some of these microorganisms are able to survive in extreme marine environments and, as a result, they produce complex molecules with unique biological interesting properties for a wide variety of industrial and biotechnological applications. Thus, different marine microorganisms (fungi, myxomycetes, bacteria, and microalgae) producing compounds with antioxidant, antibacterial, apoptotic, antitumoral and antiviral activities have been already isolated. This review compiles and discusses the discovery of bioactive molecules from marine microorganisms reported from 2018 onwards. Moreover, it highlights the huge potential of marine microorganisms for obtaining highly valuable bioactive compounds.

对新型生物活性分子的探索已扩展到筛选与较少探索的环境相关的生物体。从这个意义上说，覆盖全球近67%的海洋是有趣的生态系统，其特点是生物多样性丰富，值得探索。因此，海洋微生物作为对人类具有潜在价值的新型生物活性化合物的有希望的来源而备受关注。其中一些微生物能够在极端的海洋环境中生存，因此，它们产生具有独特的生物有趣特性的复杂分子，用于各种工业和生物技术应用。因此，已经分离出不同的海洋微生物（真菌、粘菌、细菌和微藻）产生具有抗氧化、抗菌、细胞凋亡、抗肿瘤和抗病毒活性的化合物。本综述汇编并讨论了 2018 年以来报道的从海洋微生物中发现生物活性分子的情况。此外，它凸显了海洋微生物在获取高价值生物活性化合物方面的巨大潜力。