Liver disorders may occur as a result of exposure to chemical compounds capable of inducing the oxidative stress and hepatic injuries. The aim of present study was to investigate the effects of flower extracts of B. Variegata for the treatment of liver injury induced by the CCl₄. About 1 ml/kg body weight (b.w) of CCl4 was induced to experimental mice by intraperitoneal way for 14 days. The methanol and chloroform extracts (100, 200 and 300 mg/kg b.w) were administered to experimental animals for 14 days along with standard drug Silymarine (100 mg/kg b.w). The extracts alone showed no evidence of hepatic toxicity but animals exposed to CCl₄ without the treatment with B. Variegata presented variations in levels of liver enzymes, antioxidant enzymes, proteins and blood cells as well as injuries in liver cells were also observed during histopathological study. However, after the treatments especially with 300 mg/kg b.w of methanol flower extracts levels of liver markers (ALT, AST and ALP), antioxidant enzymes and blood cells decreases and turned towards normal levels. Whereas level of total proteins and bilirubin was improved and damaged liver cells were repaired. The curative activity of flower extracts can be correlated to the higher potential of antioxidants and occurrence of Quercetin and some other organic compounds those were investigated from flower extracts of B. Variegata during HPLC and GC-MS analysis. The finding of this study supports the use of B. Variegata flower formulation in folk medicines.

肝脏疾病可能是由于接触能够诱发氧化应激和肝损伤的化合物而发生的。本研究的目的是探讨斑叶菊花提取物治疗CCl ₄引起的肝损伤的效果。以约1ml/kg体重(bw)的CCl4腹腔注射方式对实验小鼠进行诱导14天。将甲醇和氯仿提取物（100、200和300毫克/千克体重）与标准药物水飞蓟素（100毫克/千克体重）一起给予实验动物14天。单独的提取物没有显示出肝毒性的证据，但未经B.Variegata 治疗而暴露于 CCl ₄的动物的肝酶、抗氧化酶、蛋白质和血细胞水平出现变化，并且在组织病理学研究中还观察到肝细胞损伤。然而，经过特别是300毫克/公斤体重的甲醇花提取物治疗后，肝脏标记物（ALT、AST和ALP）、抗氧化酶和血细胞的水平下降并恢复到正常水平。而总蛋白和胆红素水平得到改善，受损的肝细胞得到修复。花提取物的治疗活性可能与较高的抗氧化剂潜力以及槲皮素和其他一些有机化合物的存在相关，这些化合物是从B花提取物中研究的。HPLC 和 GC-MS 分析过程中的杂色。本研究的结果支持B的使用。民间药物中的杂色花配方。