Objective

Cross-sectional studies report relations between low nasal nitric oxide (nNO) and poor asthma control and between low nNO and chronic rhinosinusitis (CRS). In our cohort study, we studied if changes in nNO related to changes in asthma control, symptoms of CRS, or asthma or rhinitis medication.

Methods

A total of 196 subjects with predominantly mild to moderate asthma, aged 10–35 years, performed nNO measurements at both baseline and follow-up after a median of 43 (range 23–65) months. Asthma control, CRS symptoms, and medication, were questionnaire-assessed at both timepoints. IgE sensitisation against aeroallergens was quantified at baseline.

Results

There was an increase in nNO between baseline and follow-up (764 ± 269 ppb vs. 855 ± 288 ppb, p < 0.001). When adjusted for covariates, a larger increase in nNO was found in subjects sensitised to perennial aeroallergens than those not sensitised (92 (16–167) ppb), as well as in subjects with daily use of inhaled corticosteroids (ICS) at baseline but not at follow-up than those on ICS daily at both timepoints (146 (51–242) ppb). In the same model, subjects using nasal steroids daily at both timepoints had decreased nNO compared with those without such treatment at both timepoints (−185 (−321–(-48)) ppb). No relations between changes in nNO levels and changes in asthma control or symptoms of CRS were found.

Conclusion

Longitudinal changes in nNO were not related to changes in asthma control, but were related to changes in asthma or rhinitis medication.

中文翻译：

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纵向哮喘队列研究中鼻一氧化氮与哮喘特征的关系

客观的

横断面研究报告了低鼻一氧化氮 (nNO) 与哮喘控制不佳之间以及低 nNO 与慢性鼻窦炎 (CRS) 之间的关系。在我们的队列研究中，我们研究了 nNO 的变化是否与哮喘控制、CRS 症状或哮喘或鼻炎药物的变化有关。

方法

共有 196 名以轻度至中度哮喘为主的受试者，年龄在 10-35 岁之间，在中位时间为 43（范围 23-65）个月后，在基线和随访时均进行了 nNO 测量。在两个时间点对哮喘控制、CRS 症状和药物治疗进行问卷评估。对空气过敏原的 IgE 致敏在基线进行量化。

结果

基线和随访之间 nNO 增加（764 ± 269 ppb 与 855 ± 288 ppb，p < 0.001）。当对协变量进行调整后，与未致敏的受试者（92 (16–167) ppb）相比，对常年性吸入性过敏原敏感的受试者以及在基线时每天使用吸入性皮质类固醇 (ICS) 的受试者中发现 nNO 的增加更大，但未发现在两个时间点（146 (51–242) ppb）的随访中，每天都比 ICS 上的那些。在同一模型中，在两个时间点每天使用鼻类固醇的受试者与在两个时间点均未接受此类治疗的受试者相比，nNO 降低 (-185 (-321–(-48)) ppb)。未发现 nNO 水平的变化与哮喘控制或 CRS 症状的变化之间存在关系。

结论

nNO 的纵向变化与哮喘控制的变化无关，但与哮喘或鼻炎药物的变化有关。