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Biocatalysis – key enabling tools from biocatalytic one-step and multi-step reactions to biocatalytic total synthesis
New Biotechnology ( IF 4.5 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.nbt.2020.08.006 Roland Wohlgemuth 1
New Biotechnology ( IF 4.5 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.nbt.2020.08.006 Roland Wohlgemuth 1
Affiliation
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In the area of human-made innovations to improve the quality of life, biocatalysis has already had a great impact and contributed enormously to a growing number of catalytic transformations aimed at the detection and analysis of compounds, the bioconversion of starting materials and the preparation of target compounds at any scale, from laboratory small scale to industrial large scale. The key enabling tools which have been developed in biocatalysis over the last decades also provide great opportunities for further development and numerous applications in various sectors of the global bioeconomy. Systems biocatalysis is a modular, bottom-up approach to designing the architecture of enzyme-catalyzed reaction steps in a synthetic route from starting materials to target molecules. The integration of biocatalysis and sustainable chemistry in vitro aims at ideal conversions with high molecular economy and their intensification. Retrosynthetic analysis in the chemical and biological domain has been a valuable tool for target-oriented synthesis while, on the other hand, diversity-oriented synthesis builds on forward-looking analysis. Bioinformatic tools for rapid identification of the required enzyme functions, efficient enzyme production systems, as well as generalized bioprocess design tools, are important for rapid prototyping of the biocatalytic reactions. The tools for enzyme engineering and the reaction engineering of each enzyme-catalyzed one-step reaction are also valuable for coupling reactions. The tools to overcome interaction issues with other components or enzymes are of great interest in designing multi-step reactions as well as in biocatalytic total synthesis.
中文翻译：
生物催化——从生物催化一步和多步反应到生物催化全合成的关键使能工具
在提高生活质量的人造创新领域，生物催化已经产生了巨大的影响，并为越来越多的催化转化做出了巨大贡献，这些催化转化旨在化合物的检测和分析、起始材料的生物转化和制备任何规模的目标化合物，从实验室小规模到工业大规模。过去几十年在生物催化领域开发的关键支持工具也为全球生物经济各个领域的进一步发展和众多应用提供了巨大的机会。系统生物催化是一种模块化、自下而上的方法，用于设计合成路线中从起始材料到目标分子的酶催化反应步骤的结构。生物催化和体外可持续化学的整合旨在实现具有高分子经济性的理想转化及其强化。化学和生物领域的逆合成分析一直是靶向合成的宝贵工具，而另一方面，面向多样性的合成建立在前瞻性分析的基础上。用于快速识别所需酶功能的生物信息学工具、高效的酶生产系统以及通用的生物过程设计工具，对于生物催化反应的快速原型设计非常重要。酶工程的工具和每个酶催化一步反应的反应工程对于偶联反应也很有价值。
更新日期：2021-01-01
中文翻译：
生物催化——从生物催化一步和多步反应到生物催化全合成的关键使能工具
在提高生活质量的人造创新领域，生物催化已经产生了巨大的影响，并为越来越多的催化转化做出了巨大贡献，这些催化转化旨在化合物的检测和分析、起始材料的生物转化和制备任何规模的目标化合物，从实验室小规模到工业大规模。过去几十年在生物催化领域开发的关键支持工具也为全球生物经济各个领域的进一步发展和众多应用提供了巨大的机会。系统生物催化是一种模块化、自下而上的方法，用于设计合成路线中从起始材料到目标分子的酶催化反应步骤的结构。生物催化和体外可持续化学的整合旨在实现具有高分子经济性的理想转化及其强化。化学和生物领域的逆合成分析一直是靶向合成的宝贵工具，而另一方面，面向多样性的合成建立在前瞻性分析的基础上。用于快速识别所需酶功能的生物信息学工具、高效的酶生产系统以及通用的生物过程设计工具，对于生物催化反应的快速原型设计非常重要。酶工程的工具和每个酶催化一步反应的反应工程对于偶联反应也很有价值。
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