Candida auris is a worrisome fungal pathogen of humans which emerged merely about a decade ago. Ever since then the scientific community worked hard to understand clinically relevant traits, such as virulence factors, antifungal resistance mechanisms, and its ability to adhere to human skin and medical devices. Whole-genome sequencing of clinical isolates and epidemiological studies outlining the path of nosocomial outbreaks have been the focus of research into this pathogenic and multidrug-resistant yeast since its first description in 2009. More recently, work was started by several laboratories to explore the biology of C. auris. Here, we review the insights of studies characterizing the mechanisms underpinning antifungal drug resistance, biofilm formation, morphogenetic switching, cell aggregation, virulence, and pathogenicity of C. auris. We conclude that, although some progress has been made, there is still a long journey ahead of us, before we fully understand this novel pathogen. Critically important is the development of molecular tools for C. auris to make this fungus genetically tractable and traceable. This will allow an in-depth molecular dissection of the life cycle of C. auris, of its characteristics while interacting with the human host, and the mechanisms it employs to avoid being killed by antifungals and the immune system.

假丝酵母是人类令人担忧的真菌病原体，仅在大约十年前才出现。从那时起，科学界一直在努力了解与临床相关的特征，例如毒力因子，抗真菌耐药性机制及其对人体皮肤和医疗设备的粘附能力。自2009年首次描述这种病原性和耐多药性酵母以来，临床分离株的全基因组测序和概述医院内爆发途径的流行病学研究一直是研究的重点。最近，一些实验室开始着手研究生物学。的C. auris。在这里，我们综述了表征抗真菌药物耐药性，生物膜形成，形态发生转换，细胞聚集，毒力和金黄色葡萄球菌致病性的机制的研究见解。我们得出的结论是，尽管已经取得了一些进展，但在我们完全了解这种新型病原体之前，我们还有很长的路要走。至关重要的是开发用于使金黄色葡萄球菌在遗传上易于处理和追溯的真菌的分子工具。这将允许生命周期的深入解剖分子C.耳，它的特性，同时与人类宿主相互作用，并且它采用的机制，以避免抗真菌药物和免疫系统被杀害。