Background

Since the pre-transplant status affects the renal transplantation success and ultimately the survival rate, identifying the probable risk factors that increase the chance of BK virus replication in end-stage renal disease patients can be included in proposing proper surveillance guidelines during pre and post-transplantation.

Methods

A descriptive cross-sectional study was performed by collecting plasma samples from 192 ESRD patients undergoing hemodialysis for at least 3 months. Quantitative Real-time PCR assay was used to detect and measure the BK viral load. Demographic and clinical characteristics of the patients who had BK viremia were documented.

Results

14 (7.3%) out of our 192 participants had BK virus viremia (95%CI 4.2%–11.6%). Demographic characteristics including etiology of ESRD and underlying diseases, mean duration and frequency of dialysis, co-infection with HBV and HCV did not affect the virus replication, since the difference between patients with BK virus viremia and BK virus negative individuals was not statistically significant. However, the statistical significance of the mean age of men with BKV and without BK virus viremia was found (OR: 3.42, P = 0.02 95%CI 0.86–13.61). Also, multiple regression analyses of some other parameters revealed that old age, high body mass index and male gender can be predictive factors of BK virus viremia in ESRD patients.

Conclusion

Based on our findings, elderly male had higher chance of being exposed to BK virus viremia. Some other demographic characteristics such as a high BMI, old age and gender (male) can increase the risk of BK viremia in patients with ESRD prior to kidney transplantation.

中文翻译：

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ESRD等待肾移植患者BK多瘤病毒复制的危险因素分析

背景

由于移植前的状况会影响肾移植的成功率，并最终影响存活率，因此，在肾移植前和移植后提出适当的监测指南时，可以识别出增加终末期肾病患者BK病毒复制机会的可能危险因素。移植。

方法

通过收集192名接受血液透析至少3个月的ESRD患者的血浆样品，进行了描述性横断面研究。实时荧光定量PCR检测用于检测和测量BK病毒载量。记录了患有BK病毒血症的患者的人口统计学和临床​​特征。

结果

在我们的192名参与者中，有14名（7.3％）患有BK病毒病毒血症（95％CI 4.2％–11.6％）。人口统计学特征包括ESRD病因和潜在疾病，平均透析时间和频率，合并感染HBV和HCV均不影响病毒复制，因为BK病毒毒血症患者和BK病毒阴性患者之间的差异无统计学意义。但是，发现有BKV和无BK病毒病毒血症的男性平均年龄的统计学意义（OR：3.42，P = 0.02 95％CI 0.86–13.61）。此外，对其他一些参数的多元回归分析表明，年龄，高体重指数和男性可能是ESRD患者BK病毒病毒血症的预测因素。

结论

根据我们的发现，老年男性更有机会接触BK病毒病毒血症。其他一些人口统计学特征，例如高BMI，高龄和性别（男性），可能会增加肾移植前ESRD患者BK病毒血症的风险。