Implant-related follow up complications resulting from poor implant integration, delamination, chipping, mechanical instability, inflammation or graft-vs-host reaction may lead to low patient tolerance, prolonged care and sometimes leading to a second surgery. Hence, there is an urgent need for developing biomaterials which will help to overcome the above compatibility problems. Ti based alloys have been widely used for biomedical applications, due to their excellent properties, such as low modulus, high biocompatibility and high corrosion resistance. In order to further improve the physical, mechanical and tribological properties of these alloys, microstructural modification is often required. Hence, this study aims to develop and evaluate the structural and tribological behavior of Hot Isostatic Pressed (HIPed) and sintered Ti-6Al-7Nb samples containing niobium, which is less toxic and less expensive as compared to the usual alloying element, vanadium (Ti-6Al-4 V). The Ti-6Al-7Nb alloys were fabricated by using nanoparticle powders milled for different durations (2, 6, 12 and 18 h) to evaluate the effect of milling time on the morphological and structural properties. Friction and wear tests were carried out on the (HIPed) and finally sintered Ti-6Al-7Nb alloy samples, to evaluate their tribological properties under different applied loads (2, 8 and 16 N), with an alumina α-Al₂O₃ ball as a counter face using an oscillating tribometer. The physical characterization of the nanopowders formed using different milling times indicated that the particle and crystallite size continually decreased with increasing milling time, while the microstrain increased. It is observed that the friction coefficient and wear rate for the samples prepared by powders milled for 18 h and tested under 2 N were lowest with values of 0.25 and 1.51 × 10^-2 µm³∙N^-1 µm^-1, respectively compared to other milled samples. This improvement in tribological properties is attributed to the grain refinement at high milling times. The antibacterial evaluation of the fabricated alloys showed an improvement in antibacterial performance of the samples milled at 18 hours compared to the other milling times.

因植入物整合不良，分层，碎裂，机械不稳定，炎症或移植物与宿主的反应不良而导致的与植入物有关的随访并发症可能导致患者耐受性差，护理时间延长，有时还会导致第二次手术。因此，迫切需要开发有助于克服上述相容性问题的生物材料。钛基合金由于其优异的性能（例如低模量，高生物相容性和高耐腐蚀性）而被广泛用于生物医学应用。为了进一步改善这些合金的物理，机械和摩擦学性能，经常需要进行微结构改性。因此，这项研究的目的是开发和评估热等静压（HIPed）和含铌的Ti-6Al-7Nb烧结样品的结构和摩擦学行为，与普通合金元素钒（Ti-6Al -4 V）。Ti-6Al-7Nb合金是通过在不同的持续时间（2、6、12和18 h）中研磨纳米颗粒粉末而制成的，以评估研磨时间对形态和结构性能的影响。在（HIPed）并最终烧结的Ti-6Al-7Nb合金样品上进行了摩擦和磨损测试，以评估在不同施加载荷（2、8和16 N）下使用氧化铝α-Al的摩擦学性能。Ti-6Al-7Nb合金是通过在不同的持续时间（2、6、12和18 h）中研磨纳米颗粒粉末而制成的，以评估研磨时间对形态和结构性能的影响。在（HIPed）并最终烧结的Ti-6Al-7Nb合金样品上进行了摩擦和磨损测试，以评估在不同施加载荷（2、8和16 N）下使用氧化铝α-Al的摩擦学性能。Ti-6Al-7Nb合金是通过在不同的持续时间（2、6、12和18 h）中研磨纳米颗粒粉末而制成的，以评估研磨时间对形态和结构性能的影响。在（HIPed）并最终烧结的Ti-6Al-7Nb合金样品上进行了摩擦和磨损测试，以评估在不同施加载荷（2、8和16 N）下使用氧化铝α-Al的摩擦学性能。使用振动摩擦计将₂ O ₃球作为对面。使用不同研磨时间形成的纳米粉体的物理表征表明，随着研磨时间的增加，颗粒和微晶尺寸不断减小，而微应变增加。据观察，通过研磨18小时，然后在2 N测试粉末制备的样品的摩擦系数和磨损率具有0.25和1.51×10值分别为最低^-2微米³ ∙Ñ ^-1 微米^-1，分别与其他研磨样品进行比较。摩擦学性能的这种提高归因于高铣削时间下的晶粒细化。对制成合金的抗菌评估表明，与其他研磨时间相比，在18小时研磨的样品的抗菌性能有所提高。