Xanthogranuloma of the sellar region has been reported in both humans and animals. The lesion is rare, and its aetiology and pathogenesis are not fully understood. The association of sellar xanthogranuloma with an adenoma, known as xanthogranulomatous pituitary adenoma (XPA), is an extremely rare condition in humans and is usually associated with anterior pituitary insufficiencies, headache, vomiting and visual deficits. We present the first report of XPA in an animal. A 7-year-old male neutered Labrador Retriever was presented for investigation of progressive lethargy, vomiting and hyporexia, having been previously diagnosed with chronic kidney disease, pituitary-dependent hyperadrenocorticism and hypoparathyroidism. The dog was euthanized due to lack of response to medical treatment and post-mortem examination revealed XPA. Although rare, xanthogranulomatous lesions should be considered in patients with pituitary disease.

鞍区黄色肉芽肿在人类和动物中均有报道。该病灶罕见，其病因和发病机制尚不完全清楚。鞍区黄色肉芽肿与腺瘤有关，称为黄色肉芽肿性垂体腺瘤 (XPA)，是人类极为罕见的疾病，通常与垂体前叶功能不全、头痛、呕吐和视力障碍有关。我们在动物中提出了 XPA 的第一份报告。一只 7 岁雄性绝育拉布拉多寻回犬因进行性嗜睡、呕吐和食欲减退而被送诊，此前已被诊断出患有慢性肾病、垂体依赖性肾上腺皮质功能亢进和甲状旁腺功能减退症。由于对医疗缺乏反应，这只狗被安乐死，尸检显示 XPA。虽然很少见，