Uraemia is a clinical syndrome caused by an increase in uraemia-associated toxins in the bloodstream as a consequence of intrinsic kidney or lower urinary tract diseases. Cats seem to be more affected by urinary tract diseases than dogs, particularly considering that chronic kidney disease (CKD) is one of the most important conditions in cats. Considering the lack of information on the systemic lesions of uraemia in cats, the aim of this study was to investigate the prevalence and clinical and pathological aspects of non-renal lesions in uraemic cats, with special attention to the differences between cats and dogs. Cats necropsied between 2000 and 2019 (n = 1,330) were investigated for urinary tract diseases and non-renal lesions of uraemia. The prevalence of uraemic cats with non-renal lesions (n = 78) was 5.8%. Adult, elderly and male animals were predominantly affected. Anorexia, apathy and vomiting were the most common clinical signs and CKD was observed in the majority of uraemic cats. Pulmonary oedema was the most frequent non-renal lesion identified. In contrast with previous reports, haemorrhagic and ulcerative gastritis was frequently observed, whereas soft tissue mineralization and parathyroid hyperplasia were uncommon features. Fibrous osteodystrophy was not observed. Cats with urinary tract diseases did not have as wide a variety of non-renal uraemic lesions as uraemic dogs and multisystemic manifestation of uraemia was observed in only 24.4% of cases.

尿毒症是一种临床综合征，由内源性肾脏或下尿路疾病导致血流中尿毒症相关毒素增加引起。猫似乎比狗更容易受到泌尿道疾病的影响，特别是考虑到慢性肾病 (CKD) 是猫最重要的疾病之一。考虑到缺乏猫尿毒症全身病变的信息，本研究的目的是调查尿毒症猫非肾脏病变的患病率和临床和病理方面，特别注意猫和狗之间的差异。对 2000 年至 2019 年间尸检的猫（n = 1,330）进行了尿路疾病和尿毒症非肾脏病变的调查。患有非肾脏病变的尿毒症猫（n = 78）的患病率为 5.8%。成人，老年和雄性动物主要受到影响。厌食、冷漠和呕吐是最常见的临床症状，在大多数尿毒症猫中观察到 CKD。肺水肿是最常见的非肾脏病变。与之前的报道相反，出血性和溃疡性胃炎经常被观察到，而软组织矿化和甲状旁腺增生是不常见的特征。未观察到纤维性骨营养不良。患有尿路疾病的猫没有尿毒症犬那样广泛的非肾脏尿毒症病变，仅在 24.4% 的病例中观察到尿毒症的多系统表现。肺水肿是最常见的非肾脏病变。与之前的报道相反，出血性和溃疡性胃炎经常被观察到，而软组织矿化和甲状旁腺增生是不常见的特征。未观察到纤维性骨营养不良。患有尿路疾病的猫没有尿毒症犬那样广泛的非肾脏尿毒症病变，仅在 24.4% 的病例中观察到尿毒症的多系统表现。肺水肿是最常见的非肾脏病变。与之前的报道相反，出血性和溃疡性胃炎经常被观察到，而软组织矿化和甲状旁腺增生是不常见的特征。未观察到纤维性骨营养不良。患有尿路疾病的猫没有尿毒症犬那样广泛的非肾脏尿毒症病变，仅在 24.4% 的病例中观察到尿毒症的多系统表现。