With increasing use of in vitro fertilization and intracytoplasmic sperm injection (IVF-ICSI) almost 2% of all babies born in the United States each year are now conceived with these technologies, making outcomes of IVF-ICSI extremely important not only to patients and families but to public health. Twin pregnancy rates after IVF-ICSI in the United States have declined since their peak in 2013 but remain at approximately 1 in 10 to 1 in 20 pregnancies. A review of the current international literature on twin versus singleton pregnancy outcomes after IVF-ICSI treatment confirms statistically significantly higher risks to maternal and perinatal health and statistically significantly higher health care costs. The field of infertility care should continue to work to develop practices that lower twin pregnancy rates to an absolute minimum to maximize the safety of these medical treatments.

中文翻译：

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支持单胎目标的当前证据：体外受精和胞浆内单精子注射后与双胎妊娠和单胎妊娠相关的孕产妇和围产期结局的回顾


随着体外受精和胞浆内单精子注射 (IVF-ICSI) 的使用不断增加，每年在美国出生的婴儿中有近 2% 是通过这些技术受孕的，这使得 IVF-ICSI 的结果不仅对患者和家庭极其重要但为了公众健康。美国 IVF-ICSI 后的双胎妊娠率自 2013 年达到峰值以来有所下降，但仍保持在大约十分之一到二十分之一的水平。对当前关于 IVF-ICSI 治疗后双胎与单胎妊娠结局的国际文献的回顾证实，孕产妇和围产期健康风险显着更高，医疗保健成本也显着更高。不孕不育护理领域应继续努力开发将双胎妊娠率降至最低的实践，以最大限度地提高这些医疗治疗的安全性。