Cortical actin waves have emerged as a widely prevalent phenomena and brought pattern formation to many fields of cell biology. Cortical excitabilities, reminiscent of the electric excitability in neurons, are likely fundamental property of the cell cortex. Although they have been mostly considered to be biochemical in nature, accumulating evidence support the role of mechanics in the pattern formation process. Both pattern formation and mechanobiology approach biological phenomena at the collective level, either by looking at the mesoscale dynamical behavior of molecular networks or by using collective physical properties to characterize biological systems. As such they are very different from the traditional reductionist, bottom-up view of biology, which brings new challenges and potential opportunities. In this essay, we aim to provide our perspectives on what the proposed mechanochemical feedbacks are and open questions regarding their role in cortical excitable and oscillatory dynamics.

皮质肌动蛋白波已作为一种广泛流行的现象出现，并将模式形成带入了细胞生物学的许多领域。皮质兴奋性，可能让人联想到神经元的电兴奋性，可能是细胞皮质的基本特性。尽管从本质上讲，它们大多被认为是生物化学的，但越来越多的证据支持力学在图案形成过程中的作用。模式形成和力学生物学都在集体层面上通过观察分子网络的中尺度动力学行为或通过使用集体物理特性来表征生物系统来处理生物现象。因此，它们与传统的还原论，自下而上的生物学观点截然不同，生物学观点带来了新的挑战和潜在的机遇。在这篇文章中