Fish oil is a nutritious product, mainly due its omega-3 polyunsaturated fatty acids (ω-3 PUFA) content that is attractive for its health benefits. Fish oil is discarded as a waste in many seafood industries, due to the lack of recovery processes to refine the oil in a lucrative and sustainable manner. This work tackles this by proposing a framework to integrate the economic, environmental and social aspects with the process design decisions of a crude fish oil refinery. The application of the framework is highlighted through production of ω-3 PUFA concentrates from waste oil of a tuna processing plant in Mexico. This is addressed by formulation and solution of a multi-objective optimization problem including intensified processing options in a superstructure. The resulting Mixed Integer Non-Linear Programing problem is solved with lexicographic and ε-constraint methods. The solutions in the form of a Pareto front are subject to benchmarking with Life Cycle Assessment (LCA) methodology. The optimal configuration consists of an intensified process with an LCA score of 458.94 and the donation 12.64 % of the ω-3 production to local communities without compromising the process profitability. Waste fish oil valorization is proven significant to achieve a circular economy model for the seafood industry.

鱼油是一种营养产品，主要是由于其omega-3多不饱和脂肪酸（ω-3PUFA）的含量对其健康有益。由于缺乏以有利可图和可持续的方式精炼鱼油的回收程序，鱼油在许多海鲜行业中被当作废物丢弃。这项工作通过提出一个框架来解决此问题，该框架将经济，环境和社会方面与粗鱼油精炼厂的工艺设计决策相结合。该框架的应用通过墨西哥金枪鱼加工厂的废油生产ω-3PUFA浓缩物得到了强调。这是通过制定和解决多目标优化问题来解决的，其中包括上层建筑中强化的加工选项。由此产生的混合整数非线性编程问题用字典法和ε约束方法解决了。帕累托阵线形式的解决方案需要使用生命周期评估（LCA）方法进行基准测试。最佳配置包括强化过程，LCA得分为458.94，将ω-3产量的12.64％捐赠给当地社区，而不会损害过程的盈利能力。事实证明，废鱼油的增值对实现海产品行业的循环经济模式具有重要意义。ω-3产量的64％用于当地社区，而不会损害过程的盈利能力。事实证明，废鱼油的增值对实现海产品行业的循环经济模式具有重要意义。ω-3产量的64％用于当地社区，而不会损害流程的盈利能力。事实证明，废鱼油的增值对实现海产品行业的循环经济模式具有重要意义。