Lyme disease (LD) is the most common tick-borne illness in Europe. Population-based studies in European children are few. This study aimed to assess the incidence, clinical presentation, treatment and outcome of serologically confirmed paediatric LD in the Republic of Ireland over a 5-year period. A retrospective review of records from accredited laboratories performing Borrelia burgdorferi serological testing was undertaken. Proformas were distributed to clinicians of children and adolescents with positive Lyme serology. Data were requested regarding clinical presentation, treatment and outcome. Updated NICE guidelines were used to classify clinical cases. Serology testing for B. burgdorferi was performed on 2908 samples. Sixty-three (2.2%) children were two-tier positive, generating a crude annual incidence rate of 1.15/100,000. Proformas were returned for 55 (87%) and 47 met clinical and laboratory criteria for LD. Twenty-seven (57%) presented with non-focal symptoms (erythema migrans and/or influenza-like symptoms), and 20 (43%) with focal symptoms (cranial nerve involvement, 11; CNS involvement, 8; arthritis, 1). Median age at presentation was 8.2 (2.5–17.9) years. Seventeen (36%) acquired LD overseas. Twenty-five (83%) of the remaining 30 children acquired infection in the West/Northwest of Ireland. Full resolution of symptoms was reported in 97% of those with available data. Serologically confirmed LD in children is relatively rare in the Republic of Ireland. Ninety-eight percent of children tested were seronegative. Of the seropositive cases, 40% could have been diagnosed based on clinical findings alone. Neurological presentations (40%) were common. Full resolution of symptoms occurred in almost all (97%) where data were available.

莱姆病 (LD) 是欧洲最常见的蜱传疾病。针对欧洲儿童的人群研究很少。本研究旨在评估爱尔兰共和国 5 年内血清学确诊的儿科 LD 的发病率、临床表现、治疗和结果。对经认可的实验室进行伯氏疏螺旋体血清学检测的记录进行了回顾性审查。表格分发给莱姆血清学阳性的儿童和青少年的临床医生。要求提供有关临床表现、治疗和结果的数据。更新的 NICE 指南用于对临床病例进行分类。伯氏疏螺旋体的血清学检测对 2908 个样本进行了分析。63 名 (2.2%) 儿童呈两级阳性，粗年发病率为 1.15/100,000。55 (87%) 和 47 符合 LD 的临床和实验室标准返回形式。27 名 (57%) 出现非局灶性症状（红斑和/或流感样症状），20 名 (43%) 出现局灶性症状（颅神经受累，11 例；CNS 受累，8 例；关节炎，1 例） . 就诊时的中位年龄为 8.2 (2.5-17.9) 岁。17 家（36%）在海外收购了 LD。其余 30 名儿童中有 25 名 (83%) 在爱尔兰西部/西北部感染。97% 有可用数据的患者报告症状完全解决。在爱尔兰共和国，经血清学证实的儿童 LD 相对罕见。98% 的接受测试的儿童血清学呈阴性。在血清阳性病例中，40% 可以仅根据临床发现进行诊断。神经系统表现 (40%) 很常见。几乎所有（97%）有数据的地方都出现了症状的完全解决。