Subclinical cardiac dysfunction is associated with smaller total brain volume on magnetic resonance imaging (MRI). To study whether cardiac output relates to regional measurements of grey and white matter structure, older adults (n = 326) underwent echocardiogram to quantify cardiac output (L/min) and brain MRI. Linear regressions related cardiac output to grey matter volumes measured on T₁ and white matter hyperintensities assessed on T₂-FLAIR. Voxelwise analyses related cardiac output to diffusion tensor imaging adjusting for demographic, genetic, and vascular risk factors. Follow-up models assessed a cardiac output x diagnosis interaction with stratification (normal cognition, mild cognitive impairment). Cardiac output interacted with diagnosis, such that lower cardiac output related to smaller total grey matter (p = 0.01), frontal lobe (p = 0.01), and occipital lobe volumes (p = 0.01) among participants with normal cognition. When excluding participants with cardiovascular disease and atrial fibrillation, associations emerged with smaller parietal lobe (p = 0.005) and hippocampal volume (p = 0.05). Subtle age-related cardiac changes may disrupt neuronal homeostasis and impact grey matter integrity prior to cognitive impairment.

亚临床心功能不全与磁共振成像 (MRI) 上较小的总脑容量有关。为了研究心输出量是否与灰质和白质结构的区域测量有关，老年人 ( n  = 326) 接受了超声心动图以量化心输出量 (L/min) 和脑部 MRI。线性回归将心输出量与在T ₁上测量的灰质体积和在T ₂ -FLAIR上评估的白质高信号相关联。Voxelwise 分析相关的心输出量与弥散张量成像调整人口统计、遗传和血管风险因素。后续模型评估心输出量 x 诊断与分层的相互作用（正常认知，轻度认知障碍）。心输出量与诊断相互作用，因此在认知正常的参与者中，较低的心输出量与较小的总灰质 ( p  = 0.01)、额叶 (p = 0.01) 和枕叶体积 (p = 0.01) 相关。当排除患有心血管疾病和心房颤动的参与者时，与较小的顶叶 ( p  = 0.005) 和海马体积 ( p  = 0.05) 相关。与年龄相关的细微心脏变化可能会破坏神经元稳态并影响认知障碍之前的灰质完整性。