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Perspective on the Role of Antibodies and Potential Therapeutic Drugs to Combat COVID-19
The Protein Journal ( IF 1.9 ) Pub Date : 2020-10-09 , DOI: 10.1007/s10930-020-09921-0
Siddhi Tandon 1 , Anchal Aggarwal 1 , Shubhra Jain 1 , Sanjay Shukla 1 , Sarika Chaudhary 1
Affiliation  

The sudden emergence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the coronavirus disease of 2019 (COVID-19) has brought the world to a standstill. Thousands of people across the globe are biting the dust with every passing day and yet more are being tested positive for the SARS-CoV-2 infection. In order to dispense this current crisis, numerous treatment options have been tried and tested and many more are still under scrutiny. The development of vaccines may help in the prevention of the global pandemic, however, there is still a need for the development of alternate approaches to combat the disease. In this review we highlight the new discoveries and furtherance in the antibody based therapeutic options and the potent drugs, with special emphasis on the development of the monoclonal and polyclonal antibodies and the repurposed drugs, which may prove to be of significant importance for the treatment of COVID-19, in the days to come. It is an attempt to evaluate the currently presented challenges so as to provide a scope for the ongoing research and assistance in the development of the effective therapeutic options against SARS-CoV-2.



中文翻译:

抗体和潜在治疗药物对抗 COVID-19 作用的观点

导致 2019 年冠状病毒病 (COVID-19) 的新型严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 的突然出现使世界陷入停滞。全球每天都有成千上万的人死去,但仍有更多人的 SARS-CoV-2 感染检测结果呈阳性。为了缓解当前的危机,已经尝试和测试了多种治疗方案,还有更多方案仍在审查中。疫苗的开发可能有助于预防全球大流行,但是仍然需要开发替代方法来对抗这种疾病。在这篇综述中,我们重点介绍了基于抗体的治疗方案和强效药物的新发现和进展,特别强调单克隆和多克隆抗体以及再利用药物的开发,这可能被证明对治疗以下疾病具有重要意义: COVID-19,在未来的日子里。它试图评估当前面临的挑战,以便为正在进行的研究提供范围,并帮助开发针对 SARS-CoV-2 的有效治疗方案。

更新日期:2020-10-11
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