Objective

To assess risk factors of transient global amnesia (TGA) recurrence.

Methods

Retrospective study of a case series of patients with the diagnosis of TGA in our neurology center in the last 8 years, identified through an anonymized database search. TGA was identified by applying Hodges and Warlow criteria.

Results

Seventy patients (70% female, average age 64.8 ± 7.8 years) were enrolled; mean follow-up was 16.5 months. More frequent co-morbidities were hypertension (50%), depression (25.7%), diabetes mellitus (17.1%), migraine (15.7%), and cerebrovascular disease (8.6%). Average TGA episode duration was 4 h. Forty-one percent had an identifiable trigger—emotional stress (25.7%), physical effort (8.6%), and sexual intercourse (4.3%). Five patients (7.1%) had hippocampus restriction on diffusion weighted MRI. Nineteen patients (27.1%) had TGA recurrence. Patients with recurrent TGA were more likely to be female and have history of depression, shorter duration episode, and hippocampus hyperintensity on brain MRI. None of the other clinical characteristics and complementary studies were predictors of recurrence. In the multivariate analysis, history of depression was the only factor found to predict which patients had a higher risk of recurrence.

Conclusion

We present a cohort of TGA patients with a considerable recurrent rate (27%), alerting for the possibility of recurrence of this clinical entity. TGA recurrence was associated with the following factors: female sex, depression, shorter episode duration, and hippocampal hyperintensity on brain MRI. History of depression was found to be the most important recurrence predictor in our study.

中文翻译：

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预测暂时性全球性失忆症复发的危险因素

目的

评估暂时性全球性健忘症（TGA）复发的危险因素。

方法

通过匿名数据库搜索在过去8年中在我们的神经病学中心对一例诊断为TGA的患者进行了回顾性研究。通过应用Hodges和Warlow标准确定了TGA。

结果

入组患者70例（女性70％，平均年龄64.8±7.8岁）；平均随访16.5个月。并发率更高的是高血压（50％），抑郁症（25.7％），糖尿病（17.1％），偏头痛（15.7％）和脑血管疾病（8.6％）。TGA平均发作持续时间为4小时。有41％的人有可识别的触发因素-情绪压力（25.7％），体力劳动（8.6％）和性交（4.3％）。5例（7.1％）患者在弥散加权MRI上有海马限制。TGA复发19例（27.1％）。患有复发性TGA的患者更有可能是女性，并且在MRI上有抑郁史，持续时间短和海马体过度紧张的病史。其他临床特征和补充研究均未预测复发。在多元分析中，

结论

我们介绍了一组相当高的复发率（27％）的TGA患者，提醒该临床实体可能复发。TGA的复发与以下因素有关：女性，抑郁，发作时间缩短和脑MRI上的海马高强度。发现抑郁史是我们研究中最重要的复发预测因子。