The safety of the tissue transplant recipient is a top priority for tissue banks, and the emergence of the new coronavirus SARS-CoV-2 has raised significant concerns about the risks of releasing tissue for clinical use. In the present study, we conducted a literature review about the potential infectivity of SARS-CoV-2 in different biological tissues and the influence of various tissue processing and sterilization procedures on viral inactivation. The search revealed that SARS-CoV-2 binds to the human angiotensin-converting enzyme receptor to penetrate human cells. These receptors are present in skin cells, musculoskeletal tissue, amniotic membranes, cardiovascular tissue and ocular tissues, including the cornea. In general, we found that coronaviruses are stable at low temperatures, and inactivated upon exposure to extreme heat and pH. Notably, gamma irradiation, which has already been employed to inactivate SARS and MERS, could be useful for sterilizing skin, amnion and musculoskeletal tissues against SARS-CoV-2. We conclude that due to the limited information about the effects of physical and chemical tissue processing methods on viral neutralization, rigorous donor screening is still essential for tissue transplant recipient safety.

组织移植受者的安全是组织库的重中之重，而新的冠状病毒SARS-CoV-2的出现引起了人们对于释放组织用于临床的风险的担忧。在本研究中，我们对SARS-CoV-2在不同生物组织中的潜在感染力以及各种组织处理和灭菌程序对病毒灭活的影响进行了文献综述。搜索显示SARS-CoV-2与人血管紧张素转换酶受体结合以穿透人细胞。这些受体存在于皮肤细胞，肌肉骨骼组织，羊膜，心血管组织和眼组织（包括角膜）中。通常，我们发现冠状病毒在低温下稳定，并且在暴露于极热和pH下会失活。值得注意的是 γ射线已被用于灭活SARS和MERS，可用于对SARS-CoV-2皮肤，羊膜和肌肉骨骼组织进行灭菌。我们得出结论，由于关于物理和化学组织处理方法对病毒中和作用的影响的信息有限，因此严格的供体筛选对于组织移植受者的安全性仍然至关重要。