This article is about my amazing immunological journey for more than a decade with Eli Sercarz as an achaarya, which in Sanskrit means enlightened mentor. My training and routine interactions with colleagues not only at Eli's laboratory but at University of California at Los Angeles, La Jolla Institute for Immunology, Torrey Pines Institute for Molecular Studies, and University of California, San Diego School of Medicine were instrumental in my continued quest to understand how activation of autoimmune inflammatory cells results in pathology and how inflammatory responses are controlled to keep us healthy. I briefly outline different aspects of immune principles related to the immune response to a self-antigen myelin basic protein (MBP) that induces experimental autoimmune encephalomyelitis, a prototype for multiple sclerosis, and how a coordinated interactive network of regulatory T cells (Tregs) CD4⁺ (CD4 Tregs) and CD8⁺ (CD8 Tregs) control the anti-MBP response to maintain immune homeostasis. Eli was my mentor, collaborator, and friend, an incredible human being, and dear member of our extended family. This article is written in his memory with unconditional gratitude.

中文翻译：

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对自身免疫反应编排中不同决定因素起反应的效应子和调节性T细胞的协调舞动

本文是关于我以Eli Sercarz作为achaarya十多年来惊人的免疫学历程的，在梵文中表示开明的导师。我不仅在Eli的实验室而且在加利福尼亚大学的洛杉矶分校，拉荷亚免疫学研究所，Torrey Pines分子研究所和加利福尼亚大学圣地亚哥分校的同事们进行的培训和例行互动，对我的继续追求都起到了重要作用了解自身免疫性炎症细胞的激活如何导致病理学以及如何控制炎症反应以保持健康。我简要概述了与自体髓磷脂碱性蛋白（MBP）的免疫反应有关的免疫原理的不同方面，该蛋白诱导实验性自身免疫性脑脊髓炎，多发性硬化症的原型，以及调节性T细胞（Tregs）CD4的协同相互作用网络⁺（CD4 Tregs）和CD8 ⁺（CD8 Tregs）控制抗MBP反应以维持免疫稳态。Eli是我的导师，合作者和朋友，是一个令人难以置信的人，也是我们大家庭的亲爱的成员。这篇文章在他的记忆中无条件感激。